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UnknownThe Opposing Roles of IVS2+691 CC Genotype and AC/AG Diplotype of 118A>G and IVS2+691G>C of OPRM1 Polymorphisms in Cold Pain Tolerance Among Opioid-Dependent Malay Males on Methadone Therapy.
Not available
S-EPMC4676768 | biostudies-literature
UnknownEndothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.
Not available
S-EPMC7285905 | biostudies-literature
TranscriptomicsCC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex CRL4CRBN, is the target of the immunomodulatory drugs lenalidomide and pomalidomide. Recently, it was demonstrated that binding of these drugs to CRBN promotes the ubiquitination and subsequent degradation of two common substra...
ORGANISM(S): Homo sapiens 
2015-11-26 | E-GEOD-75420 | biostudies-arrayexpress
ProteomicsTemporal Multi-Omic Exploration of the Ventral Tegmental Area in Chronic Pain and Passive Coping Behaviors
The comorbidity of chronic pain and mood disorders represents a significant clinical challenge, yet the underlying neurobiological mechanisms within key brain regions like the ventral tegmental area (VTA) remain poorly understood. To address this, a multidisciplinary approach was employed, combining...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-30 | PXD072701 | Pride
TranscriptomicsIdentification of transcript dysregulation in rats with a neuropathic pain, treated or not with vitamin D
Clinical observations indicate that vitamin D is a pain alleviating molecule. In order to unveil the molecular mechanisms at play, we performed an experimental study on rats with a neuropathic pain. After three weeks of vitamin D treatment, the cerebrum, the spinal cord and the dorsal root ganglia ...
ORGANISM(S): Rattus norvegicus 
2018-04-29 | E-MTAB-6801 | biostudies-arrayexpress
UnknownInhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis.
Not available
S-EPMC11895277 | biostudies-literature
TranscriptomicsC. elegans piRNAs are processed from capped-small RNAs transcribed at promoters throughout the genome
Piwi-interacting (pi) RNAs are a class of germline-expressed small RNAs that have been linked to epigenetic programming in metazoa. C. elegans piRNAs known as 21U-RNAs are defined by more than 15,000 genome-encoded species. To explore the origin of 21U-RNAs we employed methods to enrich the 5' ends ...
ORGANISM(S): Mus musculus 
2012-12-22 | E-GEOD-40053 | biostudies-arrayexpress
UnknownMale-Dominant Spinal Microglia Contribute to Neuropathic Pain by Producing CC-Chemokine Ligand 4 Following Peripheral Nerve Injury.
Not available
S-EPMC11987877 | biostudies-literature
ClinicalFeasibility Study of a Novel Single Use Robotic Colonoscopy System
This is a single centre, non-randomized, tandem colonoscopy trial of the NISInspire-C System, followed immediately by a conventional colonoscope (CC). Each trial subject will undergo colonoscopy using the NISInspire-C system, followed immediately by CC. The purpose of this study is to obtain observa...
2307836 | ecrin-mdr-crc
TranscriptomicsGene expression profiling in cumulus cells (CC) derived from a modified natural and stimulated in vitro fertilization (IVF) procedures
Cumulus cells surrounding mature oocytes that developed to moruale/blastocyst stage on day 5 of IVF cycle were collected and used for gene expression profiling using Affymetrix Human Gene 1.0 ST Arrays in order to determine differences in gene expression between the modified natural and stimulated i...
ORGANISM(S): Homo sapiens 
2014-01-10 | E-GEOD-43684 | biostudies-arrayexpress
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