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ProteomicsThe Angiostrongylus vasorum excretory/secretory proteome contains putative modulators of the host coagulation
Angiostrongylus vasorum is a cardiopulmonary nematode of canids and is, among others associated with bleeding disorders in dogs. The pathogenesis of coagulopathies remains unclear. We performed a deep proteomic characterization of sex specific A. vasorum excretory/secretory proteins (ESP) and of cut...
ORGANISM(S): Angiostrongylus vasorum 
2021-11-03 | PXD027520 | Pride
Angiostrongylus vasorum Excretory/secretory Cuticular surface 
no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
ProteomicsA chemical proteomic analysis of illudin-interacting proteins
The illudin natural product family are fungal secondary metabolites with a characteristic spirocyclopropyl-substituted fused 6,5-bicyclic ring system. They have been extensively studied for their cytotoxicity in various tumor cell types and semisynthetic derivatives with improved therapeutic charact...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD014175 | Pride
Illudins Activity based protein profiling 
ProteomicsAn antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis
The spread of antibiotic resistance is a major challenge for treatment of Mycobacterium tuberculosis infection. In addition, efficacy of drugs is often limited by the restricted permeability of the mycomembrane. Frontline antibiotics inhibit mycomembrane biosynthesis leading to rapid cell death. Ins...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) Mycobacterium tuberculosis H37Rv 
2022-01-19 | PXD007699 | Pride
Antibiotics Mycobacterium tuberculosis Lipidomics Activity-based protein profiling 
TranscriptomicsRemodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation
The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription progr...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-71774 | biostudies-arrayexpress
GenomicsThr172 phospho-AMPK ChIP-seq in mouse liver
The aim of the experiment is to define p-AMPK binding sites across the genome upon mice starvation and treatment with Dexamethasone (GR ligand) and GW7647 (PPAR alpha ligand).
ORGANISM(S): Mus musculus 
2020-10-01 | E-MTAB-7301 | biostudies-arrayexpress
TranscriptomicsComparison of the Biological Effects of Long-Term Treatment of Human Bronchial Epithelial Cells with 3R4F Cigarette Smoke or THS2.2 Aerosol Total Particulate Matter (mRNA data)
Cigarette smoking is the leading cause of lung cancer worldwide. Carcinogens in smoke produced during the combustion of cigarette tobacco are responsible for airway epithelial changes underlying lung carcinogenesis. Reduction of harmful constituents by heating rather than combusting tobacco would be...
ORGANISM(S): Homo sapiens 
2018-03-08 | E-MTAB-5697 | biostudies-arrayexpress
TranscriptomicsComparison of the Biological Effects of Long-Term Treatment of Human Bronchial Epithelial Cells with 3R4F Cigarette Smoke or THS2.2 Aerosol Total Particulate Matter (microRNA data)
Cigarette smoking is the leading cause of lung cancer worldwide. Carcinogens in smoke produced during the combustion of cigarette tobacco are responsible for airway epithelial changes underlying lung carcinogenesis. Reduction of harmful constituents by heating rather than combusting tobacco would be...
ORGANISM(S): Homo sapiens 
2018-03-08 | E-MTAB-6119 | biostudies-arrayexpress
GenomicsDUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes
Ectopic expression of the double homeodomain transcription factor DUX4 causes facioscapulohumeral muscular dystrophy (FSHD). Mechanisms of action of DUX4 are currently unknown. Using immortalized human myoblasts with a titratable DUX4 transgene, we identify by mass spectrometry an interaction betwee...
ORGANISM(S): Homo sapiens 
2016-03-10 | E-GEOD-78158 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dfferentiation of human bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction
Differentiation of bone marrow derived hMSC with beta-glycerphosphate, ascorbicacidphosphate and dexamethasone for 21 days;evaluated time points d4, d7, d14 and d21 after induction; reference d-1 (one day before induction; preconfluent 70-80%)
ORGANISM(S): Homo sapiens 
2007-06-09 | E-MARS-3 | biostudies-arrayexpress
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