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ProteomicsInteractome of P21 Activated Kinase 1 (PAK1) in oligodendrocytes
In the central nervous system (CNS), myelin formation by oligodendrocytes (OLs) relies on actin dynamics. Actin polymerization supports the ensheathment step, when the OL process contacts and surrounds a selected portion of axon. While a drastic shift to actin depolymerization is then required to en...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-03 | PXD044344 | Pride
Mass spectrometry Oligodendrocyte Pak1 (p21 activated kinase 1) Timstof pro 
TranscriptomicsComparative gene profiling study: Pak1 deficient mouse breast cancer cells vs Pak1 wt breast cancer cells
To identify differentially regulated genes between wild-type and Pak1 deficient mouse breast cancer cells, we performed a comparative gene profiling study by using mouse whole genome arrays. We compared the gene expression profiles of Her2 positive : Pak1 deficient cells vs Her2 positive : Pak1 wild...
ORGANISM(S): Mus musculus 
2016-07-23 | E-GEOD-71282 | biostudies-arrayexpress
TranscriptomicsComparative gene profiling study: Pak1 deficient human breast cancer cells vs Pak1 wt breast cancer cells
To identify differentially regulated genes between wild-type and Pak1 deficient human breast cancer cells, we performed a comparative gene profiling study by using human whole genome arrays. We compared the gene expression profiles of MCF10A.B2 cells (MCF10A cells expressing a chemically activatable...
ORGANISM(S): Homo sapiens 
2016-07-23 | E-GEOD-71283 | biostudies-arrayexpress
TranscriptomicsPak1-ATF2 signaling axis induces miR-132 to inhibit hematogenous metastasis
Pak1 as a serine/threonine kinase, has been implicated in cytoskeletal remodelling, cell motility, apoptosis and transformation. Pak1 plays important roles in multiple signal pathways. Pak1 protects cells from apoptosis through at least three different pathways including forkhead box O1 (FOXO1), B-c...
ORGANISM(S): Homo sapiens 
2016-07-16 | E-GEOD-84298 | biostudies-arrayexpress
TranscriptomicsPAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome
Poor clinical outcome of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) has been attributed to failure of current chemotherapeutic regimens to target leukemic stem cells. We recently identified p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX)...
ORGANISM(S): Homo sapiens 
2015-07-11 | E-GEOD-70791 | biostudies-arrayexpress
ProteomicsPAK1 activation as a common mechanism of endocrine therapy resistance in luminal A breast cancer models
Breast cancer is a highly heterogeneous disease, representing the most frequent malignancy and the second leading cause of cancer-related mortality in women worldwide. Among breast cancer subtypes, estrogen receptor-positive (ER+) tumors are often treated with endocrine therapies such as Tamoxifen o...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD063393 | Pride
Endocrine therapy Breast cancer Therapy resistance Phosphoproteomics 
TranscriptomicsIdentification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profiling
The purpose of the study was to identify new PAK1 targets in response to ionizing radiation with putative role in the DNA damage response. We examined the effect of IR on the gene expression patterns in the murine embryonic fibroblasts with or without Pak1 using microarray. Differentially expressed ...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-47503 | biostudies-arrayexpress
GenomicsPhospho-antibody microarray analyses for wild-type and Pak1-deficient breast cancer cells
Phospho-antibody microarray analyses for wild-type and Pak1-deficient breast cancer cells
PRJNA791654 | ENA
ProteomicsA ubiquitin-based effector-to-inhibitor switch coordinates brain, craniofacial, and skin development
The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and craniofacial structures are unclear. Here, biochemical disease-variant profiling reveals a posttranslational pathway that drives early ectodermal ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-14 | MSV000090711 | MassIVE
ProteomicsDefining how Pak1 regulates cell polarity and cell division in fission yeast
For polarized growth of cells, protein kinases regulate the assembly of cytoskeletal structures at the correct time and place. Large cytoskeletal structures must also be assembled in a regulated manner during cytokinesis and cell separation. We performed a visual screen to identify cell polarity pro...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2019-07-02 | MSV000084047 | MassIVE
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