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GenomicsA role for Pak2 kinase in cellular senescence and organismal aging
A role for Pak2 kinase in cellular senescence and organismal aging
PRJNA422413 | ENA
GenomicsInhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10
Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10
PRJNA1372162 | ENA
GenomicsExpression data after PAK2 knockdown in head and neck cancer cells
Expression data after PAK2 knockdown in head and neck cancer cells
PRJNA450818 | ENA
TranscriptomicsA role for Pak2 kinase in cellular senescence and organismal aging
Cellular senescence is an irreversible cell growth arrest state linked to loss of tissue function and aging in mammals. The cellular transition from proliferation to senescence is marked by increased expression of the cell-cycle inhibitor p16INK4A and formation of senescence-associated heterochromat...
ORGANISM(S): Mus musculus 
2019-12-31 | GSE108081 | GEO
TranscriptomicsInhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10
Tumor angiogenesis is driven by pro-angiogenic factors and results in a disorganized tumor vasculature that limits effective perfusion and immune infiltration. The p21-activated kinase 2 (PAK2) regulates endothelial cell (EC) migration, an essential step of angiogenesis, yet its role in tumor angiog...
ORGANISM(S): Homo sapiens Mus musculus 
2025-12-10 | GSE312096 | GEO
GenomicsHigh-resolution CRISPR/Cas9 screens identify PAK2 as a suppressor of macrophage proliferation and macropinocytosis.
High-resolution CRISPR/Cas9 screens identify PAK2 as a suppressor of macrophage proliferation and macropinocytosis.
PRJNA1055665 | ENA
ProteomicsMacrophage PAK2 controls the SIRPα immune checkpoint via cytoskeletal dynamics and endocytic trafficking
Professional phagocytes are essential for immunomodulation, antimicrobial control, and initiation and resolution of inflammation. These cells rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity requires a network of positive and negative regulators to control...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-31 | PXD062325 | Pride
Pak2 Endocytic trafficking. Sirpα immune checkpoint Macrophage 
UnknownHuntingtin promotes cell survival by preventing Pak2 cleavage.
Not available
S-EPMC2714430 | biostudies-literature
UnknownPak2 kinase promotes cellular senescence and organismal aging.
Not available
S-EPMC6613284 | biostudies-literature
ProteomicsInactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed group I PAK member, affects the development of malignant mesothe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD030571 | Pride
Conditional knockout mice  malignant mesothelioma  nf2 and cdkn2a tumor suppressor genes  pak  hedgehog and wnt signaling  cancer stem cells 
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