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UnknownThe hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases.
Not available
S-EPMC2655257 | biostudies-literature
UnknownS- to N-Palmitoyl Transfer During Proteomic Sample Preparation.
Not available
S-EPMC4794353 | biostudies-literature
UnknownThe Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases.
Not available
S-EPMC2898910 | biostudies-literature
ProteomicsIdentification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause Neuronal Ceroid Lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation on molecular dissection of disease mechanisms and...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD032052 | Pride
Synapse Synaptic vesicle endocytosis Neuronal ceroid lipofuscinosis Na+/k+ transporting atpase Palmitoyl protein thioesterase 1 Synaptic adhesion molecules Zdhhc Neurodegeneration Palmitoylation Disulfide bond 
ProteomicsBuilding a Cardiac Palmitoyl-Proteome
High-throughput experiments suggest that almost 20% of human proteins may be S-palmitoylated, a post-translational modification (PTM) whereby fatty acyl chains are reversibly linked to cysteine thiol group. This PTM has an impact on protein trafficking, distribution and function. There is no informa...
ORGANISM(S): Canis Lupus Familiaris (ncbitaxon:9615) Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) 
2020-08-21 | MSV000085994 | MassIVE
UnknownPalmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus.
Not available
S-EPMC4825924 | biostudies-literature
TranscriptomicsEvidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function
Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycerol-2-phosphatidylcholine (PAPC), referred to as OxPAPC, accumulate in atherosclerotic lesions and regulate over 1000 genes in human aortic endothelial cells (HAEC). We previously demonstrated that OxPAPC covalently binds to a number of prote...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-35709 | biostudies-arrayexpress
UnknownSubstrate recognition by the cell surface palmitoyl transferase DHHC5.
Not available
S-EPMC4267385 | biostudies-literature
TranscriptomicsTranscription profiling of UV- or oxidized lipid treated dermal skin fibroblasts
Long wavelength Ultraviolet (UVA-1) radiation causes oxidative stress that leads to the formation of noxious substances within the skin. As a defensive mechanism skin cells produce detoxifying enzymes and antioxidants when they detect modified molecules. We have recently shown that UVA-1 irradiation...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13606 | biostudies-arrayexpress
UnknownThe Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission.
Not available
S-EPMC4630622 | biostudies-literature
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