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ProteomicsIdentification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause Neuronal Ceroid Lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation on molecular dissection of disease mechanisms and...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD032052 | Pride
Synapse Synaptic vesicle endocytosis Neuronal ceroid lipofuscinosis Na+/k+ transporting atpase Palmitoyl protein thioesterase 1 Synaptic adhesion molecules Zdhhc Neurodegeneration Palmitoylation Disulfide bond 
TranscriptomicsTranscription profiling of palmitoyl protein thioesterase-1 knockout mice
Infantile neuronal ceroid lipofuscinosis (aka infantile Batten disease) is a severe neurodegenerative disorder of early childhood characterized by cortical atrophy, blindness and seizures, leading to premature death in the first decade. The disorder is caused by deficiency in a soluble lysosomal enz...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6678 | biostudies-arrayexpress
UnknownPalmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin.
Not available
S-EPMC12459315 | biostudies-literature
TranscriptomicsPalmitoyl protein thioesterase-1 knockout mice hofma-affy-mouse-370000
Infantile neuronal ceroid lipofuscinosis (aka infantile Batten disease) is a severe neurodegenerative disorder of early childhood characterized by cortical atrophy, blindness and seizures, leading to premature death in the first decade. The disorder is caused by deficiency in a soluble lysosomal enz...
ORGANISM(S): Mus musculus 
2007-01-09 | GSE6678 | GEO
ProteomicsIdentification of palmitoyl protein thioesterase 1 substrates defines roles for synaptic depalmitoylation
We report here the identification of substrates of the depalmitoylating enzyme PPT1 by quantitative mass spectrometry. We utilized a stringent two-step Acyl Resin-Assisted Capture (Acyl RAC) screen in which increased palmitoylation in vivo in PPT1 knockout is the first selection criteria for substra...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD017270 | Pride
Synapse Synaptic cleft Synaptic vesicle endocytosis Neuronal ceroid lipofuscinoisis Synaptic adhesion molecules Ampa receptor Neurodegeneration Palmitoylation Palmitoyl protein thioesterase 1 
UnknownIdentifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function.
Not available
S-EPMC2914843 | biostudies-literature
UnknownThe Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function.
Not available
S-EPMC6424868 | biostudies-literature
UnknownThe crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Not available
S-EPMC18274 | biostudies-literature
Unknownpdf1, a palmitoyl protein thioesterase 1 Ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease.
Not available
S-EPMC387660 | biostudies-literature
UnknownPalmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast.
Not available
S-EPMC7593845 | biostudies-literature
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