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TranscriptomicsSILENCING OF PNPLA6, THE NEUROPATHY TARGET ESTERASE (NTE) CODIFYING GENE, ALTERS HUMAN NEURODIFFERENTIATION IN VITRO
Neuropathy Target Esterase (NTE) is a protein involved in the development of a polyneuropathy caused by exposure to certain organophosphorus compounds. In vivo and in vitro studies have also associated NTE with embryonic development since NTE null mice embryos are non-viable, and silencing the NTE-c...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-55761 | biostudies-arrayexpress
TranscriptomicsEffect of Pnpla6 gene silencing in D3 mouse embryonic stem cells
Pnpla6 gene was silenced in D3 mouse embryonic stem cells and the cells were allowed to spontaneously differentiate. Transcription of the whole genome was analyzed 96 days afterwards and compared against control cells differentiated during the same time without previous silencing. Comparimg two expe...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-33974 | biostudies-arrayexpress
TranscriptomicsGenomic and phenotypic alterations of the neuronal-like cells derived from the human embryonal carcinoma stem cells (NT2) caused by exposure to the organophosphorus compounds paraoxon and mipafox
hNT2 under neurodifferentiation were exposed during 4 days to 1 µM of the non-neuropathic organophosphorus compound paraoxon and 5 µM of the neuropathic organophosphorus compound and afterwards transcriptomics were analysed and compared regarding control non-exposed cells Exposure to paraoxon caus...
ORGANISM(S): Homo sapiens 
2012-10-18 | E-GEOD-38050 | biostudies-arrayexpress
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