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GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
TranscriptomicsTranslation initiation at a non-AUG start codon for mouse and human NELF-B
Negative elongation factor (NELF), a four-subunit protein complex in metazoan, plays an important role in regulating promoter-proximal pausing of RNA polymerase II (RNAPII). Genetic studies demonstrate that the B subunit of mouse NELF (NELF-B) is critical for embryonic development and homeostasis i...
ORGANISM(S): Mus musculus 
2014-10-11 | E-GEOD-62248 | biostudies-arrayexpress
TranscriptomicsHeart tissue from Nelf-b CreER mice
Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains unclear. Here we show for the first time that whole-b...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54372 | biostudies-arrayexpress
UnknownFirst case of fungemia caused by a rare and pan-echinocandin resistant yeast <i>Sporopachydermia lactativora</i> in China.
Not available
S-EPMC12096653 | biostudies-literature
GenomicsCohesin and CTCF Differentially Affect the Chromatin Architecture and Gene Expression in Human Cells
Recent studies of genome-wide chromatin interactions have revealed that the human genome is partitioned into many self-associating topological domains. The boundary sequences are enriched for binding sites of CTCF and the cohesin complex, implicating these two factors in the establishment or mainten...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-44267 | biostudies-arrayexpress
GenomicsGlobal Reorganization of Chromatin Architecture during Embronic Stem Cell Differentiation
The 3D organization of the genome is important for regulation of diverse nuclear processes ranging from transcription to DNA replication. Knowledge of the higher order chromatin structure is critical for understanding mechanisms of gene regulation by long-range control elements such as enhancers and...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-52457 | biostudies-arrayexpress
UnknownEffects of glycyrrhetinic acid β on growth and virulence of Aeromonas hydrophila.
Not available
S-EPMC9950564 | biostudies-literature
UnknownImpact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease.
Not available
S-EPMC5023997 | biostudies-literature
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