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MetabolomicsPantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii
Coenzyme A (CoA) is an essential molecule acting in metabolism, post-translational modification, and regulation of gene expression. While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, paras...
2022-03-21 | MTBLS2501 | MetaboLights
TranscriptomicsTranscriptomic comparison of osteocyte cell lines – determining their utility as models to study sex hormone regulation of skeletal function
Comparions of transcriptomes of two osteocyte cell lines under conditions that increase and decrease androgens. To study gene expression differences and the cell lines' appropriateness for studying androgen regulation of skeletal function
ORGANISM(S): Mus musculus 
2026-09-01 | E-MTAB-16564 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of endometrioid ovarian adenocarcinomas by conditional inactivation of the PTEN and APC genes
Fifty million plaque-forming units of AdCre was injected into the right ovarian bursal cavity of 56- 70 day old female mice. Mice were euthanized 63 days later to obtain ovary tumors and normal ovary tissue. Seven individual ovarian tumors and 4 individual normal ovary samples were each assayed on...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5987 | biostudies-arrayexpress
UnknownJNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.
Not available
S-EPMC7181303 | biostudies-literature
MetabolomicsGNPS - Serum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | GNPS
TranscriptomicsProfiling protease and protease inhibitor gene expression in tumors and their microenvironment
To assist in the identification of proteases, their endogenous inhibitors, and proteins that interact with proteases or proteolytic pathways in biological tissues, a dual species oligonucleotide microarray has been developed in conjunction with Affymetrix, Inc. To investigate the performance of the ...
ORGANISM(S): Homo sapiens 
2008-07-20 | E-GEOD-6413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ovarian tumors and normal ovaries
99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell carcinomas) and 4 individual normal ovary samples, each assayed on an Affymetrix HG_U133A array Experiment Overall Design: 99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell c...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6008 | biostudies-arrayexpress
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
UnknownSemisynthetic Glycoconjugate Vaccine Candidates against Escherichia coli O25B Induce Functional IgG Antibodies in Mice.
Not available
S-EPMC9516715 | biostudies-literature
TranscriptomicsGene expression changes in the female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxin and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. We investigated the gene expression profile in ...
ORGANISM(S): Danio rerio 
2010-09-30 | E-GEOD-22662 | biostudies-arrayexpress
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