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An increase in the incidence of aneuploidy is well documented with increasing maternal age, in particular in human females. Remarkably, little is known regarding the underlying molecular basis for the age-associated increase in aneuploidy, which is a major source of decreased fertility in humans. Us...
ORGANISM(S): Mus musculus 
Genes containing multiple polyadenylation (polyA) sites express mRNA isoforms with variable 3’ untranslated regions (3’UTRs). We found that short and long 3’UTR isoforms were relatively more abundant when genes were highly and lowly expressed, respectively, in human and mouse cells. Consistently, up...
ORGANISM(S): Mus musculus 
We used three siRNAs to silence HSPA8 in MDA-MB-468 cells, and then used RNA-seq to compare HSPA8 knockdown cells with the controls.
ORGANISM(S): Homo sapiens 
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