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ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
UnknownIdentification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis.
Not available
S-EPMC10290155 | biostudies-literature
UnknownGenomic insights of Pannonibacter phragmitetus strain 31801 isolated from a patient with a liver abscess.
Not available
S-EPMC5727363 | biostudies-literature
UnknownThe Development and Synthesis of a CdZnS @Metal-Organic Framework ZIF-8 for the Highly Efficient Photocatalytic Degradation of Organic Dyes.
Not available
S-EPMC10708100 | biostudies-literature
UnknownPolyacrylonitrile Nanofiber Membrane Modified with Ag/GO Composite for Water Purification System.
Not available
S-EPMC7690632 | biostudies-literature
MetabolomicsBCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS (untargeted lipidomics)

Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone. Though POI affects many aspects of women's health, its major causes remain unknown. Many clinical studies have shown that POI patient...

2024-09-26 | MTBLS6249 | MetaboLights
UnknownAn Integrated Metabolomic Study of Osteoporosis: Discovery and Quantification of Hyocholic Acids as Candidate Markers.
Not available
S-EPMC8378234 | biostudies-literature
UnknownFour Markers Useful for the Distinction of Intrauterine Growth Restriction in Sheep.
Not available
S-EPMC10648371 | biostudies-literature
TranscriptomicsTranscriptional activity regulates alternative cleavage and polyadenylation
Genes containing multiple polyadenylation (polyA) sites express mRNA isoforms with variable 3’ untranslated regions (3’UTRs). We found that short and long 3’UTR isoforms were relatively more abundant when genes were highly and lowly expressed, respectively, in human and mouse cells. Consistently, up...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-26512 | biostudies-arrayexpress
UnknownHR-MS Based Untargeted Lipidomics Reveals Characteristic Lipid Signatures of Wilson's Disease.
Not available
S-EPMC8645799 | biostudies-literature
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