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ProteomicsPancreatic cells spectral library by the DIA strategy and the phenotype analysis of gemcitabine-sensitive
Data-independent acquisition (DIA)-mass spectrometry (MS) based proteome strategies is increasingly used for detecting and validating protein biomarkers and therapeutic targets. Here, by in-depth proteome analysis of 7 pancreatic cell lines, we built a pancreas-specific mass spectrum library contain...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032263 | Pride
Pancreatic cells spectral library 
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
MetabolomicsIncreased glucose availability sensitizes pancreatic cancer to chemotherapy
Pancreatic cancer (Pancreatic Ductal Adenocarcinoma; PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, and therefore, chemotherapy remains the best available systematic treatment. The discovery of safe and available adjuncts that can improve chemotherapeu...
2022-10-18 | MTBLS6000 | MetaboLights
ProteomicsEstablishment of pancreatic cancer cells spectral library based on data-independent acquisition strategy and the phenotype analysis of pancreatic cell lines of the sensitivity and resistance of gemcitabine
Based on data-independent acquisition (DIA)-mass spectrometry (MS) proteomics, we first established a high-coverage human pancreatic cells spectrum library. Furthermore, analyzed the sensitivity and drug resistance phenotypes to gemcitabine (GEM).
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031028 | Pride
Pancreas Gem Emt Data independent acquisition Data dependent acquisition 
MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
ProteomicsA pancreatic cancer cells spectral library and the phenotype analysis of gemcitabine-sensitive and -resistant pancreatic cell lines by the data-independent acquisition proteome strategy
Based on data-independent acquisition (DIA)-mass spectrometry (MS) strategies for in-depth proteome analysis, we established a high-coverage spectrum library from seven human pancreatic cell lines and evaluated performance of the library by exploring the molecular change between gemcitabine (GEM) se...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD030948 | Pride
Pancreas Epithelial-mesenchymal transition Data-dependent acquisition Data-independent acquisition Gemcitabine 
MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
UnknownSpectral Library-Based Single-Cell Proteomics Resolves Cellular Heterogeneity.
Not available
S-EPMC9368228 | biostudies-literature
UnknownPancreatic cancer cells spectral library by DIA-MS and the phenotype analysis of gemcitabine sensitivity.
Not available
S-EPMC9184632 | biostudies-literature
ProteomicsQuantitative Proteomic Analysis of Pancreatic Cyst Fluid Proteins Associated with Malignancy in Intraductal Papillary Mucinous Neoplasms
Intraductal papillary mucinous neoplasm (IPMN) is a benign tumor that grows within the pancreatic ducts characterized by the production of thick mucinous fluid by surrounding tumor cells. IPMN is the most important precursor lesion for pancreatic cancer that is the fourth most common cause of cancer...
ORGANISM(S): Homo sapiens (Human) 
2018-05-01 | PXD008302 | Pride
Ipmn dysplasia Mucinous cystic neoplasm (mcn) Biomarker candidates Pancreatic cyst fluid Intraductal papillary mucinous neoplasm (ipmn) Lc-ms/ms 
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