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ProteomicsProteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically heterogeneous neoplasms. We used quantitative global proteomic analysis on 40 PNENs to compliment paired transcriptome data.
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024175 | Pride
Pancreatic neuroendocrine neoplasms 
ProteomicsPeptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma)
A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082880 | MassIVE
ProteomicsPeptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma)
A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other pr...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD008465 | Pride
Plasma peptidomics Pancreatic neuroendocrine tumour Glucagonoma 
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues ...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-24358 | biostudies-arrayexpress
ProteomicsAn SRRM3 regulated neural alternative splicing program is subverted to promote tumour progression in pancreatic neuroendocrine cells.
Pancreatic neuroendocrine tumours (PanNETs) are a heterogeneous group of neoplasms arising in pancreatic islets and altering the hormone secreting function of neuroendocrine cells. Genome wide approaches have revealed the genomic landscape of PanNETs but have not explained their problematic hormone ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD065389 | Pride
Alternative splicing Microexons Pancreatic neuroendocrine tumours Insulin secretion Srrm3 
TranscriptomicsVitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) has been attributed to intrinsic resistance to chemotherapy and a growth-permissive tumor microenvironment. Quiescent pancreatic stellate cells (PSCs) are neuroendocrine, nestin-positive, lipid-accumulating cells whose homologues i...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-43770 | biostudies-arrayexpress
UnknownCirculating tumour cells and their association with bone metastases in patients with neuroendocrine tumours.
Not available
S-EPMC6353867 | biostudies-literature
UnknownModelling Pancreatic Neuroendocrine Cancer: From Bench Side to Clinic.
Not available
S-EPMC7693644 | biostudies-literature
TranscriptomicsGenome-wide methylation profiling of sporadic Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (PanNETs) account for 1-3% of all neoplasms of the pancreas. Epigenetic changes seem to be the main drivers of PanNET tumorigenesis. Indeed, the most frequent mutated genes in PanNETs are DAXX (Death domain associated protein 6), ATRX (Transcriptional Regulator ATRX)...
ORGANISM(S): Homo sapiens 
2022-11-30 | E-MTAB-11962 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation profiling of sporadic Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (PanNETs) account for 1-3% of all neoplasms of the pancreas. Epigenetic changes seem to be the main drivers of PanNET tumorigenesis. Indeed, the most frequent mutated genes in PanNETs are DAXX (Death domain associated protein 6), ATRX (Transcriptional Regulator ATRX)...
ORGANISM(S): Homo sapiens 
2022-11-30 | E-MTAB-11965 | biostudies-arrayexpress
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