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ProteomicsAn SRRM3 regulated neural alternative splicing program is subverted to promote tumour progression in pancreatic neuroendocrine cells.
Pancreatic neuroendocrine tumours (PanNETs) are a heterogeneous group of neoplasms arising in pancreatic islets and altering the hormone secreting function of neuroendocrine cells. Genome wide approaches have revealed the genomic landscape of PanNETs but have not explained their problematic hormone ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD065389 | Pride
Alternative splicing Microexons Pancreatic neuroendocrine tumours Insulin secretion Srrm3 
GenomicsRegulation of retina microexons by srrm3 in zebrafish
Regulation of retina microexons by srrm3 in zebrafish
PRJNA749559 | ENA
TranscriptomicsRegulation of retina microexons by srrm3 in zebrafish
To investigate the role of srrm3 as a regulator of retina microexons (RetMICs) we have sequenced adult retina from WT animals, and enucleated eyes from 5 dpf larvae WT and KO for srrm3.
ORGANISM(S): Danio rerio 
2022-07-01 | GSE180778 | GEO
UnknownRNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer.
Not available
S-EPMC8448969 | biostudies-literature
TranscriptomicsMJAY analysis of cerebellar RNA obtained from Srrm3 gene-trapped mice and wild-type mice
The Bronx waltzer mutation in Srrm4, a gene that encodes a neuronal Ser/Arg (SR)-rich splicing factor, disrupts the expression of several alternative exons specifically in the inner ear. Here we show that the expression of SRRM3 in neurons limits the distribution of SRRM4-dependent splicing. In vitr...
ORGANISM(S): Mus musculus 
2018-07-01 | GSE71479 | GEO
TranscriptomicsMJAY analysis of cortical RNA obtained from Srrm3-Srrm4 double mutant mice and wild-type mice
The Bronx waltzer mutation in Srrm4, a gene that encodes a neuronal Ser/Arg (SR)-rich splicing factor, disrupts the expression of several alternative exons specifically in the inner ear. Here we show that the expression of SRRM3 in neurons limits the distribution of SRRM4-dependent splicing. In vitr...
ORGANISM(S): Mus musculus 
2018-07-01 | GSE71480 | GEO
UnknownSpecialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision.
Not available
S-EPMC9303857 | biostudies-literature
GenomicsCore splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
PRJNA1155178 | ENA
GenomicsRegulation of retina microexons by SRRM3, SRRM4 and MSI1 in human cell lines
Regulation of retina microexons by SRRM3, SRRM4 and MSI1 in human cell lines
PRJNA749560 | ENA
TranscriptomicsCore splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4
Microexons are essential for proper functioning of neurons and pancreatic endocrine cells, where their inclusion depends on the splicing factors SRRM3/4. However, in pancreatic cells, their lower expression limits inclusion to only the most sensitive neuronal microexons. Although various cis-acting ...
ORGANISM(S): Homo sapiens 
2025-06-10 | GSE276143 | GEO
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