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TranscriptomicsMicroRNA expression data in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. Using miRNA expression microarrays we identified 96 differentially expressed miRNA in IPF lungs which included let-7d, miR-30 family, miR-29 fa...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27430 | biostudies-arrayexpress
TranscriptomicsGene expression data in mouse fetal lungs
Microarray data of mouse postnatal lungs between day 1 and 6 weeks of age. The results provide a general insight into the gene expression profile during the alveolar phase of lung development. We obtained lung tissue of healthy postnatal mice, 4-5 replicates at each time point. Time points were day1...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-41412 | biostudies-arrayexpress
TranscriptomicsSMAD3 targets in A549 lung epithelial cells
TGF? activates a signal transduction cascade that results in the transcription of genes, primarily through the DNA-binding transcription factor SMAD3. The objective of this study is to identify SMAD3 binding targets and the molecular pathways affected by the TGF?1/SMAD3 signal transduction on a geno...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-26858 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. The expression and role of microRNAs (miRNA) has not been studied in IPF. Using miRNA expression microarrays we identified 46 differentially ex...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-13316 | biostudies-arrayexpress
TranscriptomicsSMAD3 ChIP-on-chip on A549 cell line
The aim of this study is to identify SMAD3 binding targets affected by the TGFb1/SMAD3 signal transduction on a genome-wide scale Formaldehyde cross-linked, sonicated chromatin was prepared from non-stimulated A549 cell line and stimulated with TGFb1. Chromatin immunoprecipated with anti-SMAD3 antib...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28346 | biostudies-arrayexpress
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