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TranscriptomicsMulti-layer dosage compensation of the avian Z chromosome (bulk RNA-seq)
Sex-chromosome dosage compensation represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds...
ORGANISM(S): Gallus gallus 
2025-06-29 | E-MTAB-14443 | biostudies-arrayexpress
GenomicsMulti-layer dosage compensation of the avian Z chromosome (DNA-seq)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZZ/ZW syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14391 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of differentiating mESCs using Smart-seq3
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were adapted to 2i/LIF and female cells grown in serum/LIF conditions were differentiated using Fgf2 and Activin...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-9324 | biostudies-arrayexpress
TranscriptomicsMulti-layer dosage compensation of the avian Z chromosome (ATAC-seq)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZW/ZZ syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14390 | biostudies-arrayexpress
TranscriptomicsMulti-modal single-cell sequencing of differentiating mESCs using Smart-seq3 and scATAC-seq
We report dynamics of X-chromosome upregulation (XCU) along X-chromosome inactivation (XCI) in mESCs as they differentiate into EpiSCs. F1 hybrid C57BL6/J × CAST/EiJ male and female mESCs were grown in serum/LIF conditions were differentiated using Fgf2 and Activin A for 1, 2, 4 and 7 days to induce...
ORGANISM(S): Mus musculus 
2022-02-14 | E-MTAB-10714 | biostudies-arrayexpress
TranscriptomicsMulti-layer dosage compensation of the avian Z chromosome (Ribo-seq)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZW/ZZ syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14393 | biostudies-arrayexpress
TranscriptomicsMulti-layer dosage compensation of the avian Z chromosome (single-cell RNA-seq)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZW/ZZ syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14470 | biostudies-arrayexpress
GenomicsMulti-layer dosage compensation of the avian Z chromosome (MINUTE-ChIP)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZW/ZZ syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14392 | biostudies-arrayexpress
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