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TranscriptomicsRNA content of transcription factories
We have develop a simple fact method to isolate transcription factories and analyzed their RNA content as compared to total poly(A)+ and chromatin associated RNA fractions in presence or absence of pro-inflammatory cytokine.
ORGANISM(S): Homo sapiens 
2015-10-30 | E-MTAB-3020 | biostudies-arrayexpress
GenomicsExploiting native forces to capture chromosome conformation in mammalian cell nuclei
Here, we developed a novel chromosome conformation capture (3C) method for capturing the 3D spatial contacts of endogenous genomic loci without a need for crosslinking. This method, i3C, was applied to multiple loci in two different human primary (ENCODE) cell lines, HUVEC and IMR90, and in the abse...
ORGANISM(S): Homo sapiens 
2016-12-10 | E-MTAB-4719 | biostudies-arrayexpress
ProteomicsCHD6 IP from human induced pluripotent stem cells LC-MS-MS
Members of the chromodomain-helicase-DNA binding (CHD) protein family are chromatin remodelers implicated in human pathologies, with CHD6 being one of its least studied members. We discovered a de novo CHD6 missense mutation in a patient clinically presenting the rare Hallermann-Streiff syndrome (HS...
ORGANISM(S): Homo sapiens (Human) 
2021-03-20 | PXD024803 | Pride
Human ipscs Hallermann-streiff syndrome Chd6 immunoprecipitation Chd6 overexpression Lc-ms/ms 
GenomicsTNFalpha signaling primes chromatin for NF-kappaB binding and induces rapid and widespread nucleosome repositioning
Background The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signaling reshapes the chromatin landscape, in 3D space and over time, to allow the establishment of new transcriptional programs. Results Using micrococcal nuclease tre...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-53343 | biostudies-arrayexpress
GenomicsGenomic instability is an early event driving chromatin organization and “escape” from oncogene-induced senescence
Genomic instability is an early event driving chromatin organization and “escape” from oncogene-induced senescence
PRJNA685841 | ENA
GenomicsAtypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
Atypical K6-linked ubiquitylation marks toxic RNA-protein crosslinks induced by formaldehyde
PRJNA933609 | ENA
UnknownThe proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-kappaB / RELA
Not available
S-SCDT-10_1038-S44319-024-00339-8 | biostudies-other
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