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TranscriptomicsRNA-seq comparing WT to Dax1, Nr5a2 and Dax1/Nr5a2 knock-out clones in 2iLIF and SL differentiation conditions
Determine the transcriptomic effects that are associated with the knock-out of the inhibitor of PrE trans-differentiation Dax1 and the associated nuclear receptor Nr5a2.
This experiment is part of the study: "Mechanistic framework of lineage restriction in embryonic stem cells" by Olivieri et al.
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-9447 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq comparing WT, HDAC3 and Dax1 knock-out clones in SL(RA) differentiation conditions
We performed single-cell RNA-seq in order to characterize in high resolution the transcriptomic profiles, differentiation fates and heterogeneity of wild-type, HDAC3 or Dax1 knock-out cells in SL(RA) differentiation conditions.
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-10147 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparing WT to HDAC3 and Dax1 knock-out clones in cell-sorted populations in 2iLIF and SL(RA) differentiation conditions
In order to determine the transcriptomic profiles of PrE-induced cells following HDAC3 or Dax1 knock-out in SL(RA) differentiation conditions, RNA-seq was performed on Gata6+ or Nanog+ sort-selected cells. Profiles are contrasted with WT cells in the same differentiation conditions as well as to mo...
ORGANISM(S): Mus musculus 
2021-03-15 | E-MTAB-10150 | biostudies-arrayexpress
TranscriptomicsiCLIP transcriptome-wide mapping of UNR (CSDE1) binding sites
Analysis of UNR (CSDE1) binding to RNA targets by iCLIP transcriptome-wide mapping.
ORGANISM(S): Homo sapiens 
2016-11-07 | E-MTAB-3818 | biostudies-arrayexpress
TranscriptomicspolyA+ and total RNA sequencing profiling of UNR (CSDE1) knock down
Investigation of the effects of UNR (CSDE1) knock-down on transcript levels of Melanoma Cells.
ORGANISM(S): Homo sapiens 
2016-10-31 | E-MTAB-3805 | biostudies-arrayexpress
TranscriptomicsFunctional splicing network reveals extensive regulatory plasticity of the core Spliceosomal machinery
Pre-mRNA splicing relies on the still poorly understood dynamic interplay between more than 150 protein components of the Spliceosome, and the steps at which splicing can be regulated remain largely unknown. Here we systematically analyze the effect of knocking down the components of the splicing...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-56605 | biostudies-arrayexpress
TranscriptomicsIdentification of regulators of exit from naïve pluripotent state by enhancer trap integration site mapping
To identify regulators of exit from the naïve pluripotent state we performed an enhancer trap screen under sensitized conditions. Briefly, haploid mouse ESCs with a Puromycin resistance gene under the control of Oct4 regulatory elements were mutagenized using viruses harboring enhancer trap construc...
ORGANISM(S): Mus musculus 
2021-07-07 | E-MTAB-9796 | biostudies-arrayexpress
TranscriptomicsTimecourse RNA-seq of kidney organoid development in control and WT1-knockout iPSCs
Absence of WT1 during kidney organoid development from human induced pluripotent stem cells (iPSCs) induces hallmarks of Wilms tumorigenesis. To define underlying transcriptional alterations and similarities to human patients, we performed timecourse RNA-seq of kidney organoid development from contr...
ORGANISM(S): Homo sapiens 
2021-08-01 | E-MTAB-9957 | biostudies-arrayexpress
GenomicsEGAS00001000374 - samples
Deep RNA sequencing in CLL
EGAD00001000258 | EGA
GenomicsU219-array-CLL-00001000374 - samples
CLL Expression Array
EGAD00010000472 | EGA
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