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TranscriptomicsExpression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway 22 pancreatic cell l...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45757 | biostudies-arrayexpress
TranscriptomicsExpression Data from 24 orthotopic tumors grown in the pancreas of mice +/- MEK inhibitor PD0325901
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway 6 pancreatic cell li...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45758 | biostudies-arrayexpress
TranscriptomicsExpression Data from pancreatic cancer cell lines and orthotopic tumors grown with and without MEK inhibitor
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45765 | biostudies-arrayexpress
TranscriptomicsCharacterization of Directly Regulated Thyroid Hormone Mediated Gene Expression Following Short-Term Perturbations in Thyroid Hormone Levels in Juvenile Mice
We investigated the effects of thyroid hormone disruptions on gene expression in juvenile mice liver to develop a stronger understanding of the mechanisms by which thyroid disrupting chemicals impair development. Gene expression was examined by hybridization of hepatic RNA to Agilent mouse microarr...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-21307 | biostudies-arrayexpress
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
UnknownDevelopment of a Portfolio Diet Score and Its Concurrent and Predictive Validity Assessed by a Food Frequency Questionnaire.
Not available
S-EPMC8398786 | biostudies-literature
UnknownEvaluation of Neural Regulation and Microglial Responses to Brain Injury in Larval Zebrafish Exposed to Perfluorooctane Sulfonate.
Not available
S-EPMC10650473 | biostudies-literature
UnknownThe dominance-diversity dilemma in animal conservation biology.
Not available
S-EPMC10042335 | biostudies-literature
TranscriptomicsGlutathione-induced elicitation of defense responses in Lotus japonicus.
To identify transcription factors involved in the production of defense-related phytochemicals through co-expression studies. The changes in gene expression following GSH elicitation of leaves was followed over a time course. Four biological replicates of the unelicited samples and three biological...
ORGANISM(S): Lotus japonicus 
2011-09-15 | E-GEOD-31240 | biostudies-arrayexpress
TranscriptomicsGlobal Analysis of Thyroid Receptor Binding Sites Reveals Interaction with the Ddx54 and Thrsp Promoter in Juvenile Mouse Liver
Thyroid hormones (THs) play a critical role in development and throughout adulthood. THs act through the thyroid receptor (TR), which binds to the TH response element (TRE) to regulate the expression of target genes. Although TH action has been studied for decades, surprisingly few TREs have been we...
ORGANISM(S): Mus musculus 
2013-11-16 | E-GEOD-52417 | biostudies-arrayexpress
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