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Proteomicscomparative mass spectrometry analysis of the PARP1 and PAR-PARP1 interactomes
To investigate the functional outcome of PARP1 activation, we performed a pull-down assay coupled with comparative mass spectrometry (MS) analysis to identify proteins that are specifically associated with PAR-PARP1.
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD031109 | Pride
Human Parp1 Par-parp1 
ProteomicsPARG is Essential for Pol-theta-Mediated DNA End-Joining by Removing Repressive Poly-ADP Ribose Marks
DNA polymerase theta (Pol-theta)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Pol-theta is regulated at the molecular level to exert TMEJ remains unknown. We find that Pol-theta interacts with and is PARylated by PARP1 in vitro and in c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092839 | MassIVE
OtherIdentification of PARP1-RNA binding in-vivo using PAR-CLiP Sequencing
Recent studies have implicated PARP1 in alternative splicing regulation. In addition, PARP1 has been shown to bind RNA in vivo suggesting that it is an RNA-binding protein (RBP). However, a detailed knowledge of the RNA-targets as well as the RNA binding region of PARP1 is unknown. We used Photoacti...
ORGANISM(S): Homo sapiens 
2018-02-14 | GSE95360 | GEO
UnknownXRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.
Not available
S-EPMC11838041 | biostudies-literature
UnknownThe 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis.
Not available
S-EPMC7948984 | biostudies-literature
ProteomicsSERBP1 interactome defines its novel regulatory roles in the cytoplasm and nucleus in conjunction with PARP1-, G-quadruplex- and PAR-binders
Background RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics allow liquid-liquid phase separation (LLPS) and formation of membraneless organelles or molecular cond...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-19 | MSV000091749 | MassIVE
ProteomicsSERBP1 interactome defines its novel regulatory roles in the cytoplasm and nucleus in conjunction with PARP1-, G-quadruplex- and PAR-binders - DIA-MS data
Background RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators. Their characteristics allow liquid-liquid phase separation (LLPS) and formation of membraneless organelles or molecular cond...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-10 | MSV000093355 | MassIVE
GenomicsHomo sapiens
Identification of PARP1-RNA binding in-vivo using PAR-CLiP Sequencing
PRJNA376741 | ENA
GenomicsSERBP1 interactome defines its novel regulatory roles in the cytoplasm and nucleus in conjunction with PARP1-, G-quadruplex- and PAR-binders
SERBP1 interactome defines its novel regulatory roles in the cytoplasm and nucleus in conjunction with PARP1-, G-quadruplex- and PAR-binders
PRJEB69681 | ENA
ProteomicsMultiple roles for PARP1 in ALC1-dependent nucleosome remodeling
XL-MS mass spectrometry analysis Cross-linked peptides were resolved for mass spectrometry analysis using a Dionex UltiMate 3000 RSLnano liquid chromatography system. Peptides were initially loaded from the autosampler onto an Acclaim PepMap 100 C18 LC Trap Cartridge (0.3 mm inside diameter, 5 mm le...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-10 | MSV000087174 | MassIVE
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