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GenomicsTrichoderma harzianum strain:PAR3
Trichoderma harzianum strain:PAR3 Genome sequencing and assembly
PRJNA880851 | ENA
TranscriptomicsIdentification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form.
To development our gene expression approach, we have employed whole genome microarray expression profiling as a discovery platform to identify genes potentialy regulated by the polarity protein PAR3. Human SCC cell line, NCI-H157 (H157), has a big deletion at PARD3 locus and showed no PAR3 protein e...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-51506 | biostudies-arrayexpress
GenomicsBET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss
BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss
PRJNA1019260 | ENA
TranscriptomicsBET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss
The apical-basal polarity of pancreatic acinar cells is essential for maintaining tissue architecture. However, the mechanisms by which polarity proteins regulate acinar pancreas tissue homeostasis are poorly understood. Here, we evaluate the role of Par3 in acinar pancreas injury and homeostasis. W...
ORGANISM(S): Mus musculus 
2024-08-05 | GSE243623 | GEO
ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
GenomicsPAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration
PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration
PRJNA1181868 | ENA
TranscriptomicsInactivation of Par3/Hippo pathway promotes prostatic symmetric cell division and tumorigenesis
Purpose: mRNA sequencing has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare mRNA level of WT and Par3KO derived prostate tissues Methods: prostate mRNA profiles of 8-week-old wild-type (WT) and Par3 knockout (Par3−/−) mice were generated by sequenc...
ORGANISM(S): Homo sapiens 
2020-08-10 | GSE102503 | GEO
UnknownDual Function of Par3 in Tumorigenesis.
Not available
S-EPMC9305838 | biostudies-literature
GenomicsPAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration
The coordination of cell proliferation, polarization, and maturation with architectural assembly is crucial for liver development and regeneration, yet the mechanisms underlying this coordination remain unclear. Using both murine and human models, we demonstrate that hepatic cell polarity and bile c...
ORGANISM(S): Mus musculus 
2026-05-09 | GSE281035 | GEO
UnknownElevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.
Not available
S-EPMC5633884 | biostudies-literature
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