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ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
UnknownLocalization and importance of the adenovirus E4orf4 protein during lytic infection.
Not available
S-EPMC2643762 | biostudies-literature
UnknownStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit.
Not available
S-EPMC3650409 | biostudies-literature
UnknownAdenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly.
Not available
S-EPMC1483059 | biostudies-literature
ProteomicsGingras_Mui_E4orf4_interactions_P107_V5
This submission includes the mass spectrometry data for the manuscript by Mui et al. (E4orf4 interactome). This submission contains 16 files for E4orf4 WT or mutant interactions from HEK293 cells, acquired on LTQ Orbitrap Velos and LTQ Orbitrap Elite. See the README file within "Methods and Protoc...
ORGANISM(S): Human Adenovirus 5 (ncbitaxon:28285) Homo Sapiens (ncbitaxon:9606) 
2015-03-20 | MSV000079082 | MassIVE
UnknownThe adenoviral protein E4orf4: a probing tool to decipher mechanical stress-induced nuclear envelope remodeling in tumor cells.
Not available
S-EPMC7714506 | biostudies-literature
UnknownAdenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.
Not available
S-EPMC7147092 | biostudies-literature
UnknownAdenovirus protein E4orf4 induces premature APCCdc20 activation in Saccharomyces cerevisiae by a protein phosphatase 2A-dependent mechanism.
Not available
S-EPMC2863776 | biostudies-literature
UnknownAnalysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.
Not available
S-EPMC4442376 | biostudies-literature
UnknownIdentification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.
Not available
S-EPMC3828177 | biostudies-literature
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