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ProteomicsDiscovery of serum protein biomarkers of Active Tuberculosis in HIV- and HIV+ Individuals (US center)
The overall goal of the project is to identify candidate biomarkers of Active infection with Mycobacterium tuberculosis (Mtb) in individuals with or without HIV. Samples were analyzed from two tuberculosis (TB) endemic countries, Brazil and South Africa (SA), as well as from the United States (US). ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-22 | PXD000517 | Pride
Cohorts Tuberculosis Serum Plasma Us center hiv Latent tuberculosis Biomarker discovery 
ProteomicsDiscovery of plasma/serum protein biomarkers for progression from Mycobacterium tuberculosis infection to disease
The overall scope of this study is to find early tuberculosis (TB) candidate protein biomarkers in different TB study groups vs. controls. The identified biomarkers may become the basis of a rapid diagnostic test able to identify active TB earlier than current practice. In addition, the candidate bi...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD000582 | Pride
Disease progression Tuberculosis Discovery Early detection Biomarker Serum/plasma 
ProteomicsStudy Samples Dendritic Cell MHC II presentation by LC-MSMS
MAPPs data was used to construct an artificial neural network (ANN) model for MHC class II antigen presentation. Using Infliximab and Rituximab, the model demonstrated an unprecedented performance for predicting MAPPs and CD4 T cell epitopes, complementing results from MAPPs assays and outperforming...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD018303 | Pride
Lc-msms Mhc-associated peptide proteomics (mapps) Mhc ii presentation Dendritic cells 
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