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TranscriptomicsComparative genomic hybridization of a mother and daughter with a familial translocation t(2;6)(p25;p21) balanced in the mother and unbalanced in the daughter to determine breakpoint location and contribute to a map of haplotolerant genes
A 244 K genome-wide array based comparative genomic hybridization study was carried out in a familial translocation t(2;6)(p25;p21) balanced in the mother (SDM) and unbalanced in her daughter (SD). In the past, this translocation has allowed to localize the HLA multigene cluster to chromosome 6. Wit...
ORGANISM(S): Homo sapiens 
2008-12-31 | E-TABM-308 | biostudies-arrayexpress
ProteomicsProfiling ZO-1 interactome in endothelial cells
ZO-1 immunoprecipitation samples from BAECs, treated or not with VEGF, were analyzed using LC-MS/MS.
ORGANISM(S): Bos taurus (Bovine) 
2024-05-22 | PXD029332 | Pride
Zo-1 Proteomics Endothelial cells 
TranscriptomicsFine-tuning of human dendritic cells regulation revealed by translational profiling
Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in acco...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-14000 | biostudies-arrayexpress
TranscriptomicsThe functional benefits of cardiac progenitor cells can be equaled by their secreted extracellular vesicles
Introduction: Cell-derived extracellular vesicles ([EVs], i.e., exosomes and microparticles) have been reported to mediate the cardioprotective effects of stem cells. However, a head-to-head comparison of their effects with those of the cells from which they derive has not been reported. Hypothesis:...
ORGANISM(S): Mus musculus 
2016-05-29 | E-GEOD-69401 | biostudies-arrayexpress
ProteomicsUnraveling the Bombus terrestris hemolymph, a readout of the immune response to microbial infections, through complementary mass spectrometry approaches
Pollinators are of crucial importance for maintaining biodiversity in ecosystems and for agriculture, including the Buff-tailed bumblebee Bombus terrestris. The health decline in these populations is thought to be linked to various abiotic and biotic stressors. In the hope of protecting these popula...
ORGANISM(S): Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris) 
2023-05-10 | PXD035224 | Pride
Proteomics Response to pathogens Immune response Bumblebee Bee health Molecular fingerprints Pollinators Bacterial infections 
TranscriptomicsIGR_GLIOMA_STUDY_SP
Glioma study (gene expression and CGH): Brain tumours are the most common solid tumors in children and have the highest mortality rate of all solid pediatric tumours. Despite advances in multimodality therapy, children with high-grade gliomas invariably have an Overall Survival (OS) around 20% at 5 ...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-TABM-1107 | biostudies-arrayexpress
GenomicsHomo sapiens
Fine-tuning of human dendritic cells regulation revealed by translational profiling
PRJNA112501 | ENA
UnknownExtended spectrum of MBD5 mutations in neurodevelopmental disorders.
Not available
S-EPMC3831065 | biostudies-literature
ProteomicsInsights into the natural defences of a coral reef fish against gill ectoparasites: integrated metabolome and microbiome approach.
Understanding natural defence mechanisms against parasites can be a valuable tool for the development of innovative therapies. In this study, we investigated the interplay between the gill mucus metabolome and microbiome of Chaetodon lunulatus, a butterflyfish known to avoid gill monogeneans whilst ...
ORGANISM(S): Chaetodon lunulatus 
2020-11-25 | PXD018867 | Pride
Chaetodon Multi-omics Fish mucus Metabolomics Microbiome Host-parasite interactions Butterflyfish 
ProteomicsImpact of an antifungal insect defensin on the proteome of the phytopathogenic fungus Botrytis cinerea
ETD151, an analogue of the antifungal insect defensin heliomicin, is an antifungal peptide active against yeasts and filamentous fungi. In order to decipher the mechanisms underlying its molecular action on the phytopathogenic fungus Botrytis cinerea, a necrotrophic pathogen responsible for gray mol...
ORGANISM(S): Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) 
2020-01-29 | PXD016740 | Pride
Insect defensin Botrytis cinerea Proteomics Heliomicin Mechanism of action Fungal infection Antifungal defensin 
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