The functional benefits of cardiac progenitor cells can be equaled by their secreted extracellular vesicles

ABSTRACT: Introduction: Cell-derived extracellular vesicles ([EVs], i.e., exosomes and microparticles) have been reported to mediate the cardioprotective effects of stem cells. However, a head-to-head comparison of their effects with those of the cells from which they derive has not been reported. Hypothesis: The effects of the EV content of human embryonic stem cell (hESC)-derived cardiac progenitors may be equivalent to those of the parent cells. Methods: Two series of immunodeficient (nude) mice underwent permanent coronary artery ligation. Three weeks later, those with an echocardiographically-determined LV ejection fraction ≤ 50% were randomly allocated to receive transcutaneous echo-guided peri-infarct injections of alpha-MEM media (controls), hESC-derived SSEA-1+ cardiac progenitors (500000

ORGANISM(S): Mus musculus

SUBMITTER: Florent Dumont 

PROVIDER: E-GEOD-69401 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress