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MetabolomicsThe response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis

Drastic alteration in macronutrients causes large changes in gene expression in the photosynthetic unicellular alga Chlamydomonas reinhardtii. Preliminary data suggested that cells follow a biphasic response to this change hinging on the initiation of lipid accumulation, and we hypothesized that ...

2015-06-29 | MTBLS208 | MetaboLights
UnknownBay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.
Breast cancer cells generally develop resistance to TNF-Related Apoptosis-Inducing Ligand (TRAIL) and, therefore, assistance from sensitizers is required. In our study, we have demonstrated that Spleen tyrosine kinase (Syk) inhibitor Bay 61-3606 was identified as a TRAIL sensitizer. Amplification of...
S-EPMC4697837 | biostudies-literature
UnknownLysophosphatidylcholine Alleviates Acute Lung Injury by Regulating Neutrophil Motility and Neutrophil Extracellular Trap Formation.
Sepsis is predominantly initiated by bacterial infection and can cause systemic inflammation, which frequently leads to rapid death of the patient. However, this acute systemic inflammatory response requires further investigation from the perspectives of clinical judgment criteria and early treatmen...
S-EPMC9289271 | biostudies-literature
UnknownThree-dimensional heart extracellular matrix enhances chemically induced direct cardiac reprogramming.
Direct cardiac reprogramming has emerged as a promising therapeutic approach for cardiac regeneration. Full chemical reprogramming with small molecules to generate cardiomyocytes may be more amenable than genetic reprogramming for clinical applications as it avoids safety concerns associated with ge...
S-EPMC9750148 | biostudies-literature
UnknownClinical impact of serum exosomal microRNA in liver fibrosis.

Background/aim

We investigated alterations in the expression of serum exosomal miRNAs with the progression of liver fibrosis and evaluated their clinical applicability as biomarkers.

Methods

This study prospectively enrolled 71 patients who underwent liver biopsy at an academic hospit...
S-EPMC8432846 | biostudies-literature
UnknownReal-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method.
X-box binding protein 1 (XBP1) mRNA processing plays a crucial role in the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Upon accumulation of the UPR-converted XBP1 mRNA splicing from an unspliced (u) XBP1 (inactive) isoform to the spliced (s) ...
S-EPMC6645673 | biostudies-literature
UnknownMultistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway.
Diarrhea, a common gastrointestinal symptom in health problems, is highly associated with gut dysbiosis. The purpose of this study is to demonstrate the effect of multistrain probiotics (Sensi-Biome) on diarrhea from the perspective of the microbiome-neuron axis. Sensi-Biome (Lactiplantibacillus pla...
S-EPMC12532644 | biostudies-literature
UnknownGABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections.
Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain; however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we demonstrate that GABAergic activation enhances antimicrobial responses against intracellular bacterial infection. Intracell...
S-EPMC6180030 | biostudies-literature
UnknownArtificial Intelligence-Driven Drafting of Chest X-Ray Reports: 2025 Position Statement From the Korean Society of Thoracic Radiology Based on an Expert Survey.

Objective

Generative artificial intelligence (AI) systems can be used to draft automated chest X-ray (CXR) reports. Although promising in terms of efficiency and workforce shortages, their accuracy, reliability, and clinical utility remain uncertain. This article presents the Korean Society ...
S-EPMC12568761 | biostudies-literature
UnknownComparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells.

Background and objectives

Proficient differentiation of human pluripotent stem cells (hPSCs) into specific lineages is required for applications in regenerative medicine. A growing amount of evidences had implicated hormones and hormone-like molecules as critical regulators of proliferation ...
S-EPMC6657937 | biostudies-literature
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