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ProteomicsPhosphorylation of LARS (leucyl-tRNA synthetase) induced by amino acid stimulation
LARS undergoes structural changes in response to amino acid stimulation and translocates to lysosome, exhibiting non-canonical functions such as mTORC1 activation instead of its canonical function of tRNA amino-acylation. This study investigates which post-translational modifications (PTMs) of LARS ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD066801 | Pride
ProteomicsThe anti-metastatic effect of pyruvate dehydrogenase kinase 4 inhibition in bladder cancer via p-AKT, p-ERK, p-Src and p-JNK pathway
To confirm the anti-metastatic effect in bladder cancer cell lines, the PDK4 gene was knocked down and phosphorylated protein changes were compared through LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD035005 | Pride
Human Bladder cancer Phosphoproteomics Lc-ms/ms 
ProteomicsTailoring Polymer Surface for Long-term Reliable Xenogeneic-free Culture of Intestinal Stem Cells via Regulated Dynamic Migratory Behavior
Regenerative therapy employing intestinal stem cells (ISCs) holds a great promise for reliable epithelial restoration. However, achieving this goal requires scalable and robust, but fully defined culture platforms that eliminate the use of xenogeneic components while preserving stem cell function. M...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD064449 | Pride
Biomaterials Intestinal stem cells Plasma-treated polymers Cytoskeletal dynamics Surface engineering Regenerative medicine 
UnknownInterferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells.
Not available
S-EPMC4047854 | biostudies-literature
UnknownIsoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway.
Not available
S-EPMC7694770 | biostudies-literature
ProteomicsXenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy
Inevitable need for basement membrane extract (BME) with undefined constituents, such as Matrigel, for intestinal stem cell (ISC) culture in traditional system poses a significant barrier that must be overcome for the development of clinical-grade, scalable, ready-to-use ISCs. Here, we propose a fun...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD050747 | Pride
Intestinal tissue repair Intestinal stem cell derived from 3d human intestinal organoids (isc3d-hio) Stock banking system Xenogeneic-free culture Functional polymer coating 
UnknownPrediction of Decompensation and Death in Advanced Chronic Liver Disease Using Deep Learning Analysis of Gadoxetic Acid-Enhanced MRI.
Not available
S-EPMC9747270 | biostudies-literature
UnknownInhibition of Melanosome Transport by Inducing Exon Skipping in Melanophilin.
Not available
S-EPMC10315340 | biostudies-literature
UnknownIs Farming a Risk Occupation for Cardio-cerebrovascular Diseases? A Scoping Review on Cardio-cerebrovascular Disease Risk in Farmers.
Not available
S-EPMC11626104 | biostudies-literature
UnknownArtificial intelligence algorithm for neoplastic cell percentage estimation and its application to copy number variation in urinary tract cancer.
Not available
S-EPMC11424195 | biostudies-literature
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