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TranscriptomicsGene expression changes during development of sunitinib resistance in renal cell carcinoma patient derived xenografts
Transcriptome analysis was used to identify gene expression changes during development of sunitinib resistance in a renal cell carcinoma patient-derived xenograft (PDX) model. During the response phase, tumors exhibited a 91% reduction in volume, characterized by induction of TNFRSF1A, TNFAIP3, NFK...
ORGANISM(S): Homo sapiens 
2015-12-17 | E-GEOD-76068 | biostudies-arrayexpress
ProteomicsThe exercise-regulated skeletal muscle phosphoproteome
Four healthy male volunteers (age: 24 - 27; BMI: 24.2 - 25.9 kg/m2) underwent a single bout of high-intensity bicycle exercise reaching a VO2 max approximately 95% with blood samples and muscle biopsies taken immediately pre- and post-exercise. Subjects reached 95% VO2 max in approximately 9 to 12 m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080777 | MassIVE
TranscriptomicsRNA polymerase is poised for activation across the genome
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...
ORGANISM(S): Drosophila melanogaster 
2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress
UnknownIntravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.
Not available
S-EPMC5648171 | biostudies-literature
UnknownTransient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Not available
S-EPMC8049103 | biostudies-literature
TranscriptomicsSmoking and Obesity Related Molecular Alterations in Clear Cell Renal Cell Carcinoma
Both cigarette smoking and obesity have been implicated in increased risk of clear cell renal cell carcinoma (ccRCC); however, there are limited data regarding the molecular mechanisms that underlie these associations. We used a multi-stage design to identify and validate specific molecular targe...
ORGANISM(S): Homo sapiens 
2014-01-10 | E-GEOD-46699 | biostudies-arrayexpress
GenomicsAnalysis of whole-genome copy-number variation in Crohn's disease fistula tissue
Background: CrohnM-bM-^@M-^Ys disease is presently an incurable inflammatory bowel disease. Fistulae are extensions of the intestinal tract that may form connections with other organs. These are a common complication of CrohnM-bM-^@M-^Ys disease affecting up to 50% of patients with the most common i...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-44275 | biostudies-arrayexpress
UnknownEquity and timeliness as factors in the effectiveness of an ethical prenatal sequencing service: reflections from parents and professionals.
Not available
S-EPMC11894143 | biostudies-literature
ProteomicsHuman adipose insulin resistance
Adipocytes play a major role in whole body fuel homeostasis. Integrated proteomic analysis of adipose from insulin resistant versus healthy humans or mice or in 3T3-L1 adipocytes revealed defects in the mevalonate/coenzyme Q (CoQ) biosynthesis pathway as a unifying feature of adipocyte insulin resis...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD006891 | Pride
Human obese adipose tissue insulin resistance 
ProteomicsProteomic analysis of adipocyte insulin resistance
Insulin resistance is a major risk factor for human metabolic diseases including type 2 diabetes, cardiovascular diseases and some cancers. We analysed the proteome analyses across in vitro and in vivo models of insulin resistance to find common features of insulin resistance and identified lower e...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-07 | PXD005128 | Pride
Insulin resistance Mouse Adipocyte Adipose tissue Orbitrap Lc-ms/ms 
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