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TranscriptomicsTranscription profiling of rat liver to examine aging induced alterations in hepatic gene expression
Toxicokinetic and metabolism studies are considered crucial to dose setting and interpretation of data from rodent carcinogenicity studies. The metabolism and distribution studies are usually conducted in 6 to 8 week old rodents. However cancer studies generally involve exposures from 6 weeks of a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-4270 | biostudies-arrayexpress
TranscriptomicsSf1+ mouse adrenocortical cells vs. Wnt-responsive mouse adrenocortical cells
We sought to determine which gene transcripts are enriched in Wnt-responsive adrenocortical mouse cells compared to the entire adrenocortical mouse cell population in vivo. To this end, we employed transgenic reporter mice that label Wnt-responsive cells with GFP expression (TCF/Lef:H2B-GFP mice) or...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-53981 | biostudies-arrayexpress
ProteomicsA microbiome-dependent gut brain pathway regulates motivation for exercise
Exercise exerts a wide range of beneficial effects for healthy physiology. However, the mechanisms regulating an individual's motivation to engage in physical activity remain incompletely understood. An important factor stimulating the engagement in both competitive and recreational exercise is the ...
ORGANISM(S): Mouse 
2023-03-15 | MSV000091494 | MassIVE
UnknownEvaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study.
Not available
S-EPMC6865065 | biostudies-literature
ProteomicsKinome profiling in HER2+ breast cancer patients in response to 7 days of HER2-targeting
Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respond. Anti-HER2 monoclonal antibodies, like trastuzumab or pertuzumab, and ATP active site in...
ORGANISM(S): Homo sapiens (Human) 
2021-04-09 | PXD021865 | Pride
Pertuzumab Multiplexed kinase inhibitor beads Trastuzumab Erbb2 Clinical trial Lapatinib 
UnknownSelective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.
Not available
S-EPMC6905485 | biostudies-literature
UnknownElliptic anisotropy measurement of the f<sub>0</sub>(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition.
Not available
S-EPMC12391314 | biostudies-literature
UnknownEffectiveness of Iodophor vs Chlorhexidine Solutions for Surgical Site Infections and Unplanned Reoperations for Patients Who Underwent Fracture Repair: The PREP-IT Master Protocol.
Not available
S-EPMC7139274 | biostudies-literature
UnknownA pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan.
Not available
S-EPMC9465853 | biostudies-literature
UnknownPragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study.
Not available
S-EPMC7919062 | biostudies-literature
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