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MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
ProteomicsSite-specific glycan analysis of ErbB2 in breast cancer cell SKBR-3
This study provides site-specific profiles of asparagine-linked and serine/threonine-linked glycosylations on ErbB2, a therapeutic target RTK for ErbB2-positive cancer, through structural analysis of recombinant ErbB2 extracellular region and endogenous ErbB2 from ErbB2-positive breast cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039837 | Pride
Breast cancer Glycosylation Erbb2 Her2 
TranscriptomicsIdentification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is overexpressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-42949 | biostudies-arrayexpress
TranscriptomicsActivation of different signaling pathways in the regulation of biological properties of human pancreatic cancer cells by the mucin MUC4 and the oncogenic receptor ErbB2 genes
The mucin MUC4 and its membrane partner the ErbB2 oncogenic receptor are potential actors and partners in pancreatic tumourigenesis. However, the way they function is still largely unknown. We thus undertook in this work to identify the cellular mechanisms and the intracellular signalling pathways u...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-31322 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cancer progression to study the intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors
To identify early events of erbB2-induced mammary tumorigenesis, we compared datasets from 14 genechip experiments including MMTV-neu tumors, preneoplastic neu mammary gland (adjacent neu), and age-matched, wild-type control mammary glands
ORGANISM(S): Mus musculus 
2007-09-04 | E-GEOD-2528 | biostudies-arrayexpress
ProteomicsSite-specific glycan analysis of ErbB2 in breast cancer cell BT474
This study provides site-specific profiles of asparagine-linked and serine/threonine-linked glycosylations on ErbB2, a therapeutic target RTK for ErbB2-positive cancer, through structural analysis of recombinant ErbB2 extracellular region and endogenous ErbB2 from ErbB2-positive breast cancer cells....
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039838 | Pride
Breast cancer Erbb2 Her2 
TranscriptomicsErbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation.
Exposure to ultraviolet (UV) irradiation is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States. UV irradiation has a variety of effects on the skin associated with carcinogenesis, including DNA damage and effects on signal transduction. The alterations in...
ORGANISM(S): Mus musculus 
2006-07-01 | E-GEOD-4066 | biostudies-arrayexpress
TranscriptomicsIdentification of p130Cas/ErbB2 dependent invasive signatures in transformed mammary epithelial cells.
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is over-expressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Ca...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43907 | biostudies-arrayexpress
ProteomicsSite-specific glycan analysis of epidermal growth factor receptor 2
This study provides site-specific profiles of asparagine-linked and serine/threonine-linked glycosylations on ErbB2, a therapeutic target RTK for ErbB2-positive cancer, through structural analysis of recombinant ErbB2 extracellular region and endogenous ErbB2 from ErbB2-positive breast cancer cells....
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD039834 | Pride
Glycosylation Erbb2 Her2 
ProteomicsSite-specific glycan analysis of CHO cell expressed epidermal growth factor receptor 2
This study provides site-specific profiles of asparagine-linked and serine/threonine-linked glycosylations on ErbB2, a therapeutic target RTK for ErbB2-positive cancer, through structural analysis of recombinant ErbB2 extracellular region and endogenous ErbB2 from ErbB2-positive breast cancer cells....
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD039835 | Pride
Glycosylation Erbb2 Her2 
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