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TranscriptomicsWhole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
Whole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
ORGANISM(S): Homo sapiens 
2012-09-19 | E-MTAB-812 | biostudies-arrayexpress
MetabolomicsMetabolomic Changes in Idiopathic and GBA1 Parkinson’s Disease

Background Variants in the β-glucocerebrosidase (GBA1) gene are the commonest genetic risk factor for Parkinson Disease (PD). Here, we use mass spectrometry based metabolomics to analyse serum and sebum samples from 50 genotyped participants and find differences in lipid and sugar reg...

2025-09-18 | MTBLS10743 | MetaboLights
TranscriptomicsTranscription profiling of melanized domamine neurons isolated from male and female patients with Parkinson disease to investigate gender differences
We used 500 melanized dopamine neurons isolated from post-mortem human substantia nigra pars compacta of each sample with laser capture microdissection. Total RNA was extracted with Arcturus PicoPure RNA extraction kit and amplified two times with Arcturus RiboAmp RNA amplification kit. the samples ...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-MEXP-1416 | biostudies-arrayexpress
MetabolomicsOmics data integration allows the identification of an idiopathic Parkinson’s disease signature
The vast majority of Parkinson’s disease cases are idiopathic. Unclear ethiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent across different idiopathic Parkinson’s disease (IPD) patients ...
2026-03-16 | MTBLS7740 | MetaboLights
MetabolomicsMetabolomics of sebum reveals lipid dysregulation in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...
2020-12-21 | MTBLS2266 | MetaboLights
MetabolomicsTargeted Bile Acid Metabolomic Profiling of Plasma Samples in Patients with Parkinson's Disease

Targeted LC-MS metabolomic profiling was performed on plasma samples from a validation cohort comprising 20 patients with Parkinson's disease and 20 healthy controls. The study aimed to verify altered circulating bile acid levels identified in the discovery cohort, assess correlations between bil...

2026-09-03 | MTBLS15429 | MetaboLights
TranscriptomicsTranscription profiling of human substantia nigra from postmortem brain of Parkinsons disease patients (PD)
We used microarrays to detail the global program of gene expression underlying Parkinson's disease Experiment Overall Design: Substantia nigra tissue from postmortem brain of normal and Parkinson disease patients were used for RNA extraction and hybridization on Affymetrix microarrays: 9 replicates ...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-7621 | biostudies-arrayexpress
MetabolomicsSex differences modulate blood metabolome profiles in Parkinson’s disease patients harbouring rare genetic variants

Background: Recent findings from our group indicate that sex differences in Parkinson's disease (PD) patients with idiopathic conditions or carrying pathogenic mutations significantly influence the blood occurrence of D and L-amino acids, lipids, antioxidants, and energy-related metabolites when ...

2026-06-26 | MTBLS12746 | MetaboLights
MetabolomicsPlasma metabolomics data in the Wenzhou Parkinson's disease cohort
To discriminate plasma metabolomic profiles between Parkinson’s disease (PD) and healthy controls (HC) in Wenzhou, China, we performed liquid chromatography–mass spectrometry (LC–MS) analysis in a cohort comprising 140 PD patients and 72 HC participants. Plasma samples were subjected to LC–MS metabo...
2026-08-24 | MTBLS15442 | MetaboLights
MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
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