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MetabolomicsMetabolic analysis of Parp1 ko/wt Saline & Bleo Mouse Lung Fiboblasts and Human IPF & Normal Lung Fiboblasts (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST000275 | MetabolomicsWorkbench
ProteomicsA PARP2 active site α-helix melts to permit DNA damage-induced enzymatic activation
PARP1 and PARP2 recognize DNA breaks immediately upon their formation, generate a burst of local PARylation to signal their location, and are co-targeted by all current FDA-approved forms of PARP inhibitors (PARPi) used in the cancer clinic. Recent evidence indicates that the same PARPi molecules im...
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD043794 | Pride
Parp2 Parpi Hdx-ms Active site loop 
UnknownPARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.
Not available
S-EPMC9023293 | biostudies-literature
GenomicsEffect of depletion of PARP2 on gene expression in 3 month-old pancreas from Ela-myc mice
Effect of depletion of PARP2 on gene expression in 3 month-old pancreas from Ela-myc mice
PRJNA1160298 | ENA
GenomicsGenome-wide occupation of AR, FOXA1, and H3K27AC in LNCaP cells treated with selective PARP2 inhibitor UPF-1069
Androgen receptor (AR) signaling is a key driver of prostate cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated transcription provides new opportunities for therapeutic intervention. We have previously discovered that a genetic variant in one of the DNA repair gen...
ORGANISM(S): Homo sapiens 
2019-06-24 | GSE114274 | GEO
TranscriptomicsGene expression profilings for prostate cancer cells after inhibition of PARP1 or PARP2 using pharmaceutical or siRNA-based approaches
Androgen receptor (AR) signaling is a key driver of prostate cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated transcription provides new opportunities for therapeutic intervention. We have previously discovered that a genetic variant in one of the DNA repair gen...
ORGANISM(S): Homo sapiens 
2019-06-24 | GSE114273 | GEO
GenomicsGene expression profilings for prostate cancer cells after inhibition of PARP1 or PARP2 using pharmaceutical or siRNA-based approaches
Gene expression profilings for prostate cancer cells after inhibition of PARP1 or PARP2 using pharmaceutical or siRNA-based approaches
PRJNA471001 | ENA
GenomicsGenome-wide occupation of AR, FOXA1, and H3K27AC in LNCaP cells treated with selective PARP2 inhibitor UPF-1069
Genome-wide occupation of AR, FOXA1, and H3K27AC in LNCaP cells treated with selective PARP2 inhibitor UPF-1069
PRJNA471000 | ENA
TranscriptomicsEffect of depletion of PARP2 on gene expression in 3 month-old pancreas from Ela-myc mice
Pancreatic cancer represents one of the most lethal tumours, characterised by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confers resistance to immunotherapy. Here, we demonstrate that the deletion of Poly(ADP-ribose)polymerase 2 (PARP2) delays tumour...
ORGANISM(S): Mus musculus 
2025-06-04 | GSE277055 | GEO
UnknownPARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
Not available
S-EPMC10400701 | biostudies-literature
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