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TranscriptomicsAdvancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping
Since the initial publication of the trypanosomatid genomes, curation has been ongoing. Here we apply the technique of ribosome profiling to Trypanosoma brucei, identifying 223 new coding regions by virtue of ribosome occupancy in the corresponding transcripts. A small number of these putative genes...
ORGANISM(S): Trypanosoma brucei 
2015-12-22 | E-GEOD-72463 | biostudies-arrayexpress
TranscriptomicsStage-specific regulation of translation revealed by ribosome profiling of Trypanosoma brucei
Trypanosoma brucei subspecies infect humans and animals in sub-Saharan Africa. This early diverging eukaryote shows many novel features in basic biological processes, including the use of polycistronic transcription to generate all protein-coding mRNAs. Therefore we hypothesized that translational...
ORGANISM(S): Trypanosoma brucei 
2014-05-24 | E-GEOD-57336 | biostudies-arrayexpress
TranscriptomicsMathematical modeling of Trypanosoma brucei transcription
Trypanosome RNA polymerase II transcription is polycistronic, individual mRNAs being excised by trans splicing and polyadenylation. In this study, we refined the previously published mathematical model for bloodstream form parasites and extended it to the procyclic form. We used the model, together ...
ORGANISM(S): Trypanosoma brucei 
2016-03-16 | E-GEOD-79208 | biostudies-arrayexpress
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