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TranscriptomicsDNA methylation data from primary neuroblastoma tumors
Genome wide DNA methylation profiling of primary neuroblastomas. The Illumina 450k methylation array was used to obtain DNA methylation profiles across approximately 485,000 CpGs in 105 neuroblastomas. Tumors were derived from 40 low-risk, 9 intermediate-risk and 56 high-risk patients. Bisulphite c...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73515 | biostudies-arrayexpress
TranscriptomicsRNA expression data from primary neuroblastoma tumors
RNA expression profiles of 105 primary neuroblastomas derived from customized 4 x 44k oligonucleotide microarrays (Agilent Technologies). These profiles are part of an integrative study combining genomewide epigenetic profiles with transcriptome data of the same neuroblastoma cohort. Tumors were der...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73517 | biostudies-arrayexpress
TranscriptomicsDNA methylation analysis of neuroblastoma cell lines treated with epigenetic drugs
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on the neuroblastoma methylome was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in histone modification and RNA expression. The neuroblastoma cell lines Be(...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-80243 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis of neuroblastoma cell lines treated with epigenetic drugs
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on the neuroblastoma transcriptome was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in histone modification and DNA methylation. The neuroblastoma cell line...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-79859 | biostudies-arrayexpress
GenomicsChIP-seq-based analysis of differential K27me3 coverage in neuroblastoma cell lines treated with epigenetic drugs
The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on H3K27me3 coverage was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in RNA expression and DNA methylation. The neuroblastoma cell lines Be(2)-C and IMR5-7...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-80445 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis in the MYCN-amplified neuroblastoma cell line IMR5-75 upon inducible MYCN-knockdown
Inducible MYCN-knockdown, followed by RNA-seq analysis in the MYCN-amplified neuroblastoma cell line IMR5-75, reveals profound time-dependent transcriptome changes. For modulation of MYCN levels, stable neuroblastoma cell models were used where MYCN can be downregulated via vector-based hairpin RNA...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-80397 | biostudies-arrayexpress
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