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Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS). The role of chronic inflammation in these symptoms, in par...
ORGANISM(S): Homo sapiens (Human) 
2024-11-01 | PXD050202 | Pride
Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations
Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study
Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study
Many people experiencing long COVID symptoms, or post-acute sequelae of SARS-CoV-2 infection (PASC), suffer from debilitating neurologic symptoms (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether virus-specific adaptive immunity is affected in these ind...
ORGANISM(S): Homo sapiens 
2023-05-24 | GSE225942 | GEO
Single-cell whole-genome DNA methylation profiling of whole blood from PASC patients and healthy controls
PASC (Post-Acute Sequelae of COVID-19) involves many organs, including most prominently the central nervous system. Most studies of PASC in laboratory animals were performed in the context of mild disease, but higher PASC prevalence is observed in patients with severe disease. Here, to investigate t...
ORGANISM(S): Mus musculus 
2024-02-23 | GSE254984 | GEO
Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein
We performed single-cell whole-genome bisulfite sequencing (scWGBS) on whole blood samples from three individuals with Post-Acute Sequelae of SARS-CoV-2 (PASC/Long COVID) and three healthy control individuals to characterize cell-type-specific DNA methylation alterations associated with PASC. Librar...
ORGANISM(S): Homo sapiens 
2026-09-02 | GSE341094 | GEO
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