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TranscriptomicsTranscription profiling of human leukocytes from chronic myeloid leukemia patients exhibiting differing responses to imatinib
This is a class prediction experiment, where the class is the response status to imatinib (also called Gleevec), a drug used to treat patients with chronic myelogenous leukemia (CML). There are two data sets, a training set (from Leipzig, 8 Responders and 5 Non-Responders) and a validation set (fro...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2535 | biostudies-arrayexpress
TranscriptomicsOligonucleotide expression microarray data for analysis of Wilms tumor 1 gene (WT1) mutations in cytogenetically normal acute myeloid leukemia (AML) patient samples
Oligonucleotide expression microarray data used for expression signature associated with WT1 mutations in cytogenetically normal AML patient samples
ORGANISM(S): Homo sapiens 
2011-06-17 | E-TABM-1020 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Genomic Profiling of Adult and Pediatric Core-Binding-Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Alterations
To identify cooperating lesions in core-binding-factor acute myeloid leukemia (CBF-AML), we performed single-nucleotide polymorphism (SNP)-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. We identified a mean of 1.28 copy number alterations (CNAs) per case at dia...
ORGANISM(S): Homo sapiens 
2012-02-07 | E-GEOD-32462 | biostudies-arrayexpress
TranscriptomicsDeregulated apoptosis signaling in core binding factor leukemia differentiates clinically relevant, molecular marker independent subgroups
Core binding factor (CBF) leukemias, characterized by translocations t(8;21) or inv(16)/t(16;16) targeting the core binding factor, constitute acute myeloid leukemia (AML) subgroups with favorable prognosis. However, about 40% of patients relapse, and the current classification system does not fully...
ORGANISM(S): Homo sapiens 
2011-06-11 | E-GEOD-29883 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of acute myeloid leukemia patient samples for analysis of miR-29b expression
microRNA microarray data used for analysis of miR-29b expression in AML patient samples
ORGANISM(S): Homo sapiens 
2011-03-16 | E-TABM-944 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of acute myeloid leukemia patient samples for analysis of KIT and SP1 expression
Oligonucleotide expression microarray data used for analysis of KIT and SP1 expression levels in AML patient samples
ORGANISM(S): Homo sapiens 
2011-03-16 | E-TABM-945 | biostudies-arrayexpress
TranscriptomicsGenome-wide Genotyping of Acute Myeloid Leukemia with Translocation t(9;11)(p22;q23) Reveals Novel Recurrent Genomic Alterations
To identify cooperating lesions in de novo and therapy-related acute myeloid leukemia (t-AML) with translocation t(9;11)(p22;q23) we performed high-resolution SNP-array profiling on 40 leukemia samples [de novo: n=22; t-AML: n=16; unknown: n=2]. A mean of 1.73 copy number alterations (CNAs)/case wer...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-46745 | biostudies-arrayexpress
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