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GenomicsGenome-wide maps of Rad21 in R1/E embryonic stem cells and R1/E derived Embryoid bodies
ChIP-seq based determination of Rad21 binding sites in embryonic stem cells (ESC) and ESC derived Embryoid Bodies (EB) identified Examination of Rad21 binding sites in 2 cell types
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-24029 | biostudies-arrayexpress
GenomicsGenome-wide maps of CTCF in R1/E embryonic stem cells
ChIP-seq based determination of CTCF binding sites in embryonic stem cells (ESC) Examination of CTCF binding sites
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-25777 | biostudies-arrayexpress
TranscriptomicsThe Cohesin Complex Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity
Embryonic stem cells (ESCs) cells run a self-renewal gene expression program, requiring the expression of certain transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptio...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-24030 | biostudies-arrayexpress
TranscriptomicsExpression data from Rad21 knock-down in ES cells
The Cohesin complex has recently been described to regulate gene expression. We wanted to determine the gene expression profile specific in mouse ES cells after depletion of the Cohesin subunit Rad21. We used microarrays to detail the global programme of gene expression underlying depletion of Rad21...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-23923 | biostudies-arrayexpress
TranscriptomicsGene regulation in hematopoietic cells by Pcgf1 in a Runx1 null background
The transcription factor Runx1 is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation of hematopoietic s...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33280 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.
Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68925 | biostudies-arrayexpress
GenomicsStage-specific binding profiles of cohesin in resting and activated B lymphocytes
Binding profiles of cohesin in resting mature murine splenic B lymphocytes and at two stages after cell activation were elucidated by chromatin immunoprecipitation and deep sequencing. RAD21 binding profile in resting, 48h- and 96h-stimulated B cells were analyzed in three replicates and normalized ...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61443 | biostudies-arrayexpress
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