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TranscriptomicsRNAseq of epidermis reconstructed from TSG-6-/- and TSG-6+/+ immortalized N/TERT keratinocytes and stimulated or not with interleukins 4 and 13 for 48h
TNFα-stimulated gene 6 (TSG-6) is an anti-inflammatory protein. In human epidermis, TSG-6 is secreted in extracellular matrix where it interacts with hyaluronan (HA). However, their functions are not well understood. In this study, immortalized N/TERT keratinocytes were edited by CRISPR/Cas9, used t...
ORGANISM(S): Homo sapiens 
2021-12-30 | E-MTAB-10095 | biostudies-arrayexpress
TranscriptomicsBovine adult versus prepubertal cumulus cells
The present study was undertaken to discover molecular markers in bovine cumulus cells predictive of oocyte competence and elucidate their functional significance. Differences in RNA transcript abundance in cumulus cells harvested from oocytes of adult versus prepubertal animals (model of poor oocy...
ORGANISM(S): Bos taurus 
2010-05-25 | E-GEOD-10819 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of the Small RNA Transcriptome of Normal and Malignant Human B cells Identifies Hundreds of Novel MicroRNAs: microarray analysis
A role for microRNAs has been recognized in nearly every biological system examined thus far. A complete delineation of their role must be preceded by the identification of all microRNAs present in any system. We elucidated the complete small RNA transcriptome of normal and malignant B cells through...
ORGANISM(S): Homo sapiens 
2010-08-26 | E-GEOD-22895 | biostudies-arrayexpress
UnknownDegradation and selective ligninolysis of wheat straw and banana stem for an efficient bioethanol production using fungal and chemical pretreatment.
Not available
S-EPMC3781266 | biostudies-literature
TranscriptomicsTranscription profiling of mouse C57BL/6J strain infected with Sendai virus vs. UV irradiated virus to investigate virus-induced airway disease
Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Experiment Overall Design: Whole lung RNA was analyzed from 3 mice per condition per time point for days 2...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10964 | biostudies-arrayexpress
GenomicsPolymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1
DNA methylation is an epigenetic modification that plays critical roles in gene silencing, development, and the maintenance of genome integrity. In Arabidopsis, DNA methylation is established by DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and is targeted by 24 nt small interfering RNAs (siRNAs) th...
ORGANISM(S): Arabidopsis thaliana 
2013-05-13 | E-GEOD-45368 | biostudies-arrayexpress
GenomicsDNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis.
The relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutation of the H3K27 methyltransferase genes, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, result in re-replication (repeated origin firing within the same cell cycle). He...
ORGANISM(S): Arabidopsis thaliana 
2012-08-07 | E-GEOD-38286 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cholangiocarcinoma cells (cholangiocytes) expressing IL-6
The association between chronic inflammation and the development and progression of malignancy is exemplified in the biliary tract where persistent inflammation strongly predisposes to cholangiocarcinoma. The inflammatory cytokine interleukin-6 (IL-6) enhances tumor growth in cholangiocarcinoma by a...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-11883 | biostudies-arrayexpress
UnknownSingle-Cell RNA Seq in Sydenham Chorea Shows B Cell HLA-DR/DQ Upregulation and Plasma Cell Proteasomal Activation.
Not available
S-EPMC12623827 | biostudies-literature
UnknownMutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase.
Not available
S-EPMC10727455 | biostudies-literature
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