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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
GenomicsNotch1-driven epigenetic changes in a mouse model of T cell Acute Lymphoblastic Leukemia (T-ALL)
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34954 | biostudies-arrayexpress
TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsCytokine-independent detection of antigen-specific germinal center T follicular helper (Tfh) cells in immunized non-human primates using a live cell Activation Induced Marker (AIM) technique
A range of current candidate AIDS vaccine regimens are focused on generating protective HIV neutralizing antibody responses. Many of these efforts rely on the rhesus macaque animal model. Understanding how protective antibody responses develop and how to increase their efficacy are both major knowle...
ORGANISM(S): Macaca mulatta 
2016-09-07 | E-GEOD-81382 | biostudies-arrayexpress
TranscriptomicsComparison of mRNA expression in circulating T-cells from patients with severe asthma
Comparison of mRNA expression showed widespread changes in the circulating CD8+ but not CD4+ T-cells from patients with severe asthma. No changes were observed in the CD4+ and CD8+ T-cells in non-severe asthmatics versus healthy controls. Bioinformatics analysis showed that the changes in CD8+ T-cel...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31773 | biostudies-arrayexpress
TranscriptomicsCish inhibits CD8+ T cell immunity and disrupts proximal T cell receptor signaling
T cell receptor (TCR) signaling is a critical process in immunity to infectious disease and cancer. Recently, a genome-wide association study has implicated polymorphisms in the CISH locus with susceptibility to infectious diseases. However, the role of Cish in the immune responses and its molecular...
ORGANISM(S): Mus musculus 
2015-04-30 | E-GEOD-56328 | biostudies-arrayexpress
TranscriptomicsCharacterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions
Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. Here, we compared the effects of a novel, potent and selective CRAC inhibitor, 2,6-Difluoro-N-{5-[4-m...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43210 | biostudies-arrayexpress
TranscriptomicsGene expression on in vitro T cells activated with IL-21
We have analyzed the effects of IL-21 signaling on T cell activation, IL-22 production and gut inflammation In this dataset we include the results of treating T cells with IL-21. Naïve CD4+ T cells (C57BL/6) were isolated, cultured in vitro +/- IL-21 and RNA was prepared
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55509 | biostudies-arrayexpress
ProteomicsTargeting Menin in T-Lineage Acute Lymphoblastic Leukemia
The efficacy of menin inhibition was evaluated in 14 primary T-ALL samples with diverse genetic backgrounds using ziftomenib. Sensitivity was not correlated with HOXA expression or KMT2A rearrangements, and in vivo treatment significantly reduced tumor burden in xenograft models without notable toxi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-05 | PXD065179 | Pride
Acute leukemia Menin inhibiton T-all 
UnknownSolid cancer-directed CAR T cell therapy that attacks both tumor and immunosuppressive cells via targeting PD-L1.
Not available
S-EPMC11532918 | biostudies-literature
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