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ProteomicsTMT Multiplexing-Based Quantitative Analysis of Pathogenic Th2 Proteomes.
To investigate the regulation of pathogenic Th2 (pTh2) cells and the role of histone deacetylase 1 (HDAC1) in the respective processes, we used a new in vitro protocol for generating pTh2 cells and performed qunatitative mass spectrometry analysis based on TMTpro 16plex multiplexing to analyze prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-20 | PXD042975 | Pride
Tmtpro 16plex Pathogenic th2 cells Mus musculus Th2 cells 
GenomicsEffect of HDAC1 deficiency on in vitro Th2 and pathogenic Th2 differentiated murine CD4+ T cells
Effect of HDAC1 deficiency on in vitro Th2 and pathogenic Th2 differentiated murine CD4+ T cells
PRJNA987658 | ENA
TranscriptomicsDendritic cell maturation by proinflammatory TNF or pathogenic Trypanosoma brucei antigens instruct similar T helper-2 cell responses in murine models of autoimmunity and asthma
Background Dendritic cells (DC) represent the major cell type leading to polarized T helper (Th) cell responses in vivo. The current data indicate that DC maturation under inflammatory conditions or by helminth infections induce only incomplete DC maturation bearing a partially tolerogenic potential...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-28231 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human in vitro primed Th1, Th2, Th9 and Treg T cells
To test whether human in vitro primed Th9 cells recapitulate the core pathogenic Th2 cell phenotype, we differentiated naïve T cells into Th1 (IL-12), Th2 (IL-4), Th9 (IL-4+TGF-β), and iTreg (TGF-β). After 7 days transcriptomic profiling by bulk RNA-seq was performed.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12199 | biostudies-arrayexpress
GenomicsSingle-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma
Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma
PRJNA1178293 | ENA
GenomicsDUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
PRJNA480393 | ENA
GenomicsId2 orchestrates IL-33-driven metabolic reprogramming in pathogenic Th2 cells (ChIP-seq)
Id2 orchestrates IL-33-driven metabolic reprogramming in pathogenic Th2 cells (ChIP-seq)
PRJNA1516451 | ENA
TranscriptomicsTranscription profiling of mouse naive T cells differentiated under TH1 and TH2 conditions
Naive CD4+ CD62L+ CD25- T cells were differentiated under TH1 and TH2 conditions for 7 days, restimulated with anti-CD3 and anti-CD28 for 24h and sorted for IFN-gamma (TH1) and IL-4 (TH2) production using cytokine secretion assays.
ORGANISM(S): Mus musculus 
2009-06-01 | E-MEXP-2153 | biostudies-arrayexpress
GenomicsClonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis
Clonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis
PRJNA734315 | ENA
TranscriptomicsEffect of HDAC1 deficiency on in vitro Th2 and pathogenic Th2 differentiated murine CD4+ T cells
The differentiation of naïve CD4+ T cells into distinct effector T helper (Th) subsets is controlled by the chromatin state of the cells which in turn is regulated by various epigenetic mechanisms such as reversible lysine acetylation mediated by histone acetyltransferases and histone deacetylases (...
ORGANISM(S): Mus musculus 
2025-01-23 | GSE235803 | GEO
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