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Unknown (31988)
Genomics (2435)
Transcriptomics (1702)
Proteomics (683)
Metabolomics (189)
Methylation profiling (50)
Other (50)
Genomic (19)
Clinical (13)
Models (10)
Multiomics (9)

Organisms

Homo sapiens (1260)
Mus musculus (733)
Rattus norvegicus (118)
Drosophila melanogaster (20)
synthetic construct (13)
Sus scrofa (12)
Canis lupus familiaris (6)
Macaca fascicularis (5)
Danio rerio (5)
Caenorhabditis elegans (4)
Bos taurus (3)
Betapolyomavirus hominis (3)
Mycobacterium tuberculosis (2)
Saccharomyces cerevisiae (2)
Babesia divergens (2)
Papio cynocephalus (2)
Chlamydia trachomatis (2)
Staphylococcus aureus subsp. aureus MSSA476 (2)
Macaca nemestrina (2)
Equus caballus (2)
Staphylococcus aureus (2)
Arabidopsis thaliana (2)
Staphylococcus aureus subsp. aureus MW2 (2)
Anemonia viridis (1)
Listeria monocytogenes EGD (1)
Escherichia coli UTI89 (1)
Listeria monocytogenes EGD-e (1)
Streptococcus agalactiae (1)
Ovis aries (1)
Escherichia coli str. K-12 substr. MG1655 (1)

Organisms

Homo sapiens (927)
Mus musculus (649)
Rattus norvegicus (72)
Drosophila melanogaster (11)
human gut metagenome (11)
Mycobacterium tuberculosis (7)
Macaca fascicularis (6)
Paramphistomum cervi (5)
Sus scrofa (5)
Danio rerio (4)
Mycobacterium avium complex (MAC) (2)
Hepatitis B virus (2)
Streptococcus pyogenes (2)
Equus caballus (2)
Canis lupus familiaris (2)
mouse gut metagenome (2)
Bos taurus (2)
Ophiophagus hannah (1)
Dermabacter vaginalis (1)
Babesia divergens (1)
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 (1)
Macaca nemestrina (1)
Capra (1)
Pan (1)
Mycobacterium avium complex sp. (1)
Papio cynocephalus (1)
Nothobranchius furzeri (1)
respiratory tract metagenome (1)
human nasopharyngeal metagenome (1)
Papio anubis (1)

Repository

ENA (2176)
geo (1437)
biostudies-arrayexpress (507)
pride (387)
MassIVE (179)
MetaboLights (135)
EGA (114)
iProX (57)
GNPS (54)
jPOST (36)
dbGaP (19)
PeptideAtlas (12)
BioModels (10)
PanoramaPublic (10)
ExpressionAtlas (2)
EVA (2)
GPMDB (2)

Tissue

Brain (48)
Cell culture (43)
Blood plasma (29)
Heart (20)
Blood (18)
Epithelial cell (17)
Blood serum (15)
Blood cell (14)
Liver (14)
Cerebrospinal fluid (12)
Fibroblast (12)
B cell (10)
Kidney (10)
Macrophage (9)
Primary cell (9)
Skeletal muscle (8)
Skin (7)
Urine (7)
Female Reproductive System (6)
Bone marrow (6)
Cell suspension culture (6)
Extracellular vesicle (6)
Lung (6)
Stem cell (6)
Hepatocyte (5)
Leukocyte (5)
Ovary (3)
Eye (1)
Others (1)
Urine (1)

Disease

Type 2 diabetes mellitus (9)
Disease free (7)
Alzheimer's disease (6)
Normal (5)
Colorectal Neoplasms (5)
Ovarian cancer (2)
Not Available (2)
Serous Cystadenocarcinoma (2)
Non-alcoholic steatohepatitis and chronic liver damage (1)
Acute liver damage (1)
Tauopathy (1)
XCGD (1)
High bone mineral density (1)
Keratoconus (1)
Mild hyperglycemia (1)
Active Crohn's disease (1)
Mild hyperglycemia, liver dysfunction, and renal glycosuria (1)
Pneumococcal meningitis (1)
Crohn's disease (1)
Reference (1)
Hypertensive (1)
The participants enrolled in this study will all undergo major upper abdominal surgery (i.e. mostly Pylorus Preserving Pancreatico Duodenectomy or whipple procedure) mostly for pancreatic cancer, papillary carcinoma or pancreatitis. However, the indication for which the IMP is administered is intestinal ischemia and reperfusion. (1)
Esophageal cancer Gastric cancer Colorectal cancer Liver cancer Pancreatic cancer Gallbladder and bili duct cancer Breast cancer Lung cancer (1)
Diabetes Mellitus (1)
Prostatic Neoplasms (1)
Cachexia (1)
Carcinoma (1)
Glioblastoma (1)
Colonic Neoplasms (1)
High Grade Ovarian Serous Adenocarcinoma (1)

Technology Type

Mass Spectrometry (387)
Shotgun proteomics (202)
Bottom-up proteomics (78)
Mass spectrometry (74)
Mass spectrometry assay (49)
Data-dependent acquisition (49)
Data-independent acquisition (34)
SWATH MS (30)
Affinity purification coupled with mass spectrometry proteomics (25)
Gel-based experiment (23)
NMR spectroscopy (12)
Unknown, Affymetrix 500K (11)
Top-down proteomics (11)
Affymetrix 500K, unknown (6)
Illumina HiSeq 2000 (5)
All-ion fragmentation (5)
SRM/MRM (5)
HDMSE (4)
DiaPASEF (3)
NMR spectroscopy assay (2)
ILLUMINA, NextSeq 500, Illumina HiSeq 2000 (1)
Illumina HiSeq 4000, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
HiSeq X Ten, ILLUMINA (1)
ILLUMINA, Illumina MiSeq (1)
Illumina Genome Analyzer II (1)
MSE (1)
Mass spectrometry imaging (1)
Metaproteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (28)
Illumina HiSeq 2500 (12)
Illumina HiSeq 4000 (9)
NextSeq 2000 (5)
NextSeq 550 (5)
Illumina NovaSeq X (3)
BGISEQ-500 (3)
Illumina HiSeq 3000 (3)
Illumina HiSeq 1000 (2)
Illumina HiSeq 1500 (2)
Illumina HiSeq 2000 (2)
NextSeq 500 (2)
HISeq2500 (1)
Python (1)
Nugen Ovation SPIA; Wafergen’s Apollo liquid handler; KAPA Hyper Prep Library Kit (1)
QIAGEN TissueLyser II (1)
Isoflurane euthanasia chamber (1)
Nanodrop 2000c spectrophotometer (1)
STAR (1)
Single Cell/Low Input RNA Library Prep Kit for Illumina (#E6420S, New England Biolabs) (1)
RNA Micro Kit (Qiagen). (1)
IEO HPC (1)
Covaris sonicator, PCR thermocycler, magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen mortar and pestle, benchtop microcentrifuge, vortex mixer (1)
Dissecting tools, liquid nitrogen, −80 °C freezer (1)
Controlled-environment growth chamber (short-day; 8 h light / 16 h dark) (1)
Wollenberger tongs (1)
Computer (1)
Bioinformatics Core Facility, Centre for Molecular Medicine, CEITEC Masaryk University (1)
Cell culture laboratory, BSL-3 lab (1)

Publication Date

2025 (390)
2026 (340)
2024 (275)
2023 (224)
2022 (192)
2021 (184)
2020 (148)
2016 (135)
2015 (121)
2019 (111)
2017 (95)
2018 (84)
2008 (77)
2010 (76)
2014 (75)
2012 (61)
2011 (61)
2013 (49)
2009 (47)
2007 (37)
2005 (15)
2006 (14)
2003 (2)
2004 (1)

UNIPROT ID/AC

A0A087WT59 (12)
A0A087WTX5 (12)
A0A087WVW2 (12)
A0A087WYL9 (12)
A0A087X130 (12)
A0A087X1V9 (12)
A0A0A0MS07 (12)
A0A0A0MS51 (12)
A0M8Q6 (12)
A0N5G5 (12)
A2BFH1 (12)
A2NUT2 (12)
A4F255 (12)
A5A3E0 (12)
A6NNZ2 (12)
B3KML9 (12)
O95816 (1)
Q71U36 (1)
Q16543 (1)
Q9UNE7 (1)
P19174 (1)
P10636 (1)
P50148 (1)
P11142 (1)
P02768 (1)
P08185 (1)
P17735 (1)
P08684 (1)
P04150 (1)
O75469 (1)

ENSEMBL ID

ENSG00000170477 (11)
ENSG00000229353 (11)
ENSG00000204131 (8)
ENSG00000147251 (7)
ENSG00000247315 (7)
ENSG00000198650 (1)
ENST00000355962 (1)
ENST00000336411 (1)
ENSG00000160868 (1)
ENST00000343796 (1)
ENSG00000113580 (1)
ENST00000337940 (1)
ENSG00000144852 (1)

CHEBI ID

CHEBI:16737 (29)
CHEBI:16919 (26)
CHEBI:17368 (26)
CHEBI:16704 (24)
CHEBI:15891 (24)
CHEBI:30769 (24)
CHEBI:17596 (22)
CHEBI:16027 (21)
CHEBI:17750 (21)
CHEBI:16015 (21)
CHEBI:17154 (21)
CHEBI:16761 (19)
CHEBI:15422 (15)
CHEBI:17287 (14)
CHEBI:17234 (13)
CHEBI:15846 (11)
CHEBI:26689 (1)
CHEBI:5656 (1)
CHEBI:29101 (1)
CHEBI:17138 (1)
CHEBI:16908 (1)
CHEBI:16004 (1)
CHEBI:18021 (1)
CHEBI:41879 (1)
CHEBI:16962 (1)
CHEBI:17650 (1)
CHEBI:33699 (1)
CHEBI:15361 (1)
CHEBI:16541 (1)
CHEBI:29108 (1)

Metabolite Name

Taurine (31)
Creatinine (29)
Creatine (29)
Uracil (26)
Hypoxanthine (26)
Adenosine (23)
Inosine (23)
Betaine (22)
L-Histidine (22)
Adenine (22)
Uridine (22)
Choline (21)
Xanthine (20)
Guanosine (20)
L-Tyrosine (20)
Riboflavin (19)
Cytidine (19)
L-Valine (18)
Glycerophosphocholine (17)
L-Methionine (17)
L-Phenylalanine (17)
Leucine (16)
Sphingosine (16)
Pantothenic acid (16)
L-Proline (16)
Cytosine (16)
Suberic acid (16)
Linoleic acid (16)
L-Serine (16)
Glycine (15)

First Public Date

2025 (335)
2026 (299)
2024 (277)
2014 (215)
2023 (201)
2022 (163)
2021 (163)
2020 (151)
2019 (99)
2017 (82)
2018 (73)
2015 (59)
2016 (40)
2013 (18)
2011 (1)

Modelling Approach

Ordinary differential equation model (6)
Other (1)
Constraint-based model (1)

Study status

Completed (4)
Active, not recruiting (3)
Not provided (3)
Ongoing (1)
Enrolling by invitation (1)
Terminated (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (17)
CECAD Excellence Center, University of Cologne, Germany, D-50931 Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany, D-50931 (4)
Department of pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China (4)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (4)
Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University Shanghai Medical College, Shanghai 200032, China. (4)
Cardiovascular Proteomics Laboratory & Proteomics Unit Vascular Pathophysiology Area Centro Nacional de Investigaciones Cardiovasculares Melchor Fernández Almagro núm. 3 28029 Madrid (3)
Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (3)
VIB-UGent Center for Medical Biotechnology UGent Department of Biomolecular Medicine Technologiepark-Zwijnaarde 75 B9052 Gent Belgium (3)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
CECAD Excellence Center, University of Cologne, 50931 Cologne, Germany; Department of Physiology and Pathophysiology, Faculty of Medicine, University Hospital of Cologne, 50931 Cologne, Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany; Institute of Genetics, Natural Faculty, University of Cologne, 50931 Cologne, Germany (2)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (2)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (2)
Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (2)
Faculty of Chemistry and Center for Synthetic Microbiology (SYNMIKRO) Head of the Core-Facility for Mass Spectrometry Marburg University Hans-Meerwein-Str. 4 35032 Marburg GERMANY (2)
Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences (2)
Hangzhou Medical College (2)
IRCCS Istituto G Gaslini (2)
King's College London, British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, UK (2)
LSUHSC Proteomics Core Facility Department of Biochemistry and Molecular Biology LSU Health Sciences Center New Orleans, LA 70112 (2)
Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France (2)
Molecular Physiology & Biophysics, Wright Lab, University of Iowa, USA (2)
Proteomics, Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (2)
Texas Tech University (2)
University of Wisconsin-Madison (2)
- Platelet Research Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain - Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands - Department of Medicine, University of Oviedo, Oviedo, Spain (1)
1) AGH University of Krakow, Krakow, Poland 2) Maj Institute of Pharmacology, Polish Academy od Sciences, Krakow, Poland (1)
1. Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany 2. Pediatric Neurology, University Hospital Essen, University of Duisburg-Essen, Faculty of Medicine, Essen, Germany (1)
1. Paris-Cité university, Cochin institute CNRS UMR8104, Inserm U1016, 24 rue du faubourg Saint Jacques 75014 Paris, France 2. Department of Endocrinology and National Reference Center for Rare Adrenal Disorders, Cochin hospital, Assistance Publique Hôpitaux de Paris, 24 rue du faubourg Saint Jacques 75014 Paris, France (1)
1. iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal. 2. ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal. (1)
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD (1)

Keyword

Tranexmic acid (1)
21+ years old (1)
Address (1)
Amputation (1)
Area (1)
Arm (1)
Atheroscleroses (1)
Atherosclerotic (1)
Bariatrics (1)
Behavior Conditioning Therapy (1)
Behavior Modification (1)
Behavior Therapy (1)
Behavior Treatment (1)
Behavior or Life Style Modifications (1)
Behavioral Conditioning Therapy (1)
Behavioral Modification (1)
Behavioral Therapy (1)
Behavioral Treatment (1)
Beta Cell (1)
Blood Pressure, High (1)
Blood Vessels (1)
Body Weight decreased (1)
Cancers (1)
Cardiac infarction (1)
Care, Health (1)
Cause of Death (1)
Cell Function (1)
Cell Process (1)
Cell physiology (1)
Cellular Function (1)

IsPrivate

False (10)

Model Flag

Non Kinetic (2)

Submitter Keywords

Not Peer Reviewed (1)
FROG (1)

Classification

bacteria (19)
protozoa (3)
viruses (2)

Modification

2x(15)N labeled L-lysine (3)
4x(15)N labeled L-arginine (3)
-17.026549 (1)
-18.010565 (1)
15.994915 (1)
42.010565 (1)
4x(2)H labeled dimethylated L-lysine (1)
57.021464 (1)
79.966331 (1)
N6-dimethyl-L-lysine (1)
Not available (1)

Study type

Transcription profiling by array (339)
RNA-seq of coding RNA (67)
Unknown experiment type (21)
Methylation profiling by array (12)
RNA-seq of coding RNA from single cells (12)
RNA-seq of total RNA (11)
ChIP-seq (9)
Interventional (8)
Comparative genomic hybridization by array (7)
Observational (5)
Other (3)
RNA-seq of non coding RNA (3)
Transcription profiling by SAGE (2)
ChIP-chip by array (2)
Transcription profiling by RT-PCR (2)
MicroRNA profiling by array (2)
Cell line - Single-cell sequencing (1)
Human - Single-cell sequencing (1)
Cell line - One-color microarray (1)
High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
Bisulfite-seq (1)
Exome sequencing (1)
RIP-seq (1)
Ribo-seq (1)
Single nucleus RNA sequencing (1)
DNA-seq (1)
Genotyping by high throughput sequencing (1)
Methylation profiling by high throughput sequencing (1)

Release Date

2022 (4096)
2021 (3836)
2023 (3646)
2025 (3220)
2020 (2893)
2024 (2852)
2019 (2071)
2018 (1799)
2017 (1577)
2016 (1307)
2015 (1167)
2014 (989)
2013 (568)
2012 (507)
2026 (471)
2011 (411)
2010 (336)
2009 (226)
2008 (212)
2007 (100)
2006 (69)
2005 (50)
2004 (30)
2003 (23)
2002 (14)
1999 (10)
2001 (6)
2000 (5)
1998 (2)
1995 (1)

Location

France (3)
United States (2)
Thailand (1)
Hong Kong (1)
Taiwan (1)
Denmark (1)
South Korea (1)
Japan (1)
Belgium (1)
Netherlands (1)

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Involvement of the Gut Microbes Romboutsia hominis and Akkermansia muciniphila in the Pathophysiology and Development of Nonalcoholic Steatohepatitis

Background Nonalcoholic steatohepatitis (NASH) represents a growing global health challenge due to its propensity to progress to irreversible hepatic disorders, including fibrosis, cirrhosis, and carcinoma. This study aimed to investigate the role of gut microbiota in the pathogenesis of NASH. We ha...

2025-06-23 | MTBLS12631 | MetaboLights

Metabolomics Analysis Identifies Glutamic acid and Cystine imbalances in COVID-19 Patients Without Comorbid Conditions. Implications on Redox Homeostasis and COVID-19 Pathophysiology

It is well known that the presence of comorbidities and age-related health issues may hide biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases associated to hypoxia, as they are by themselves chronic inflammatory conditions that may potentially disturb metaboli...

2024-08-26 | MTBLS5011 | MetaboLights

Expression data from rat kidney: pathophysiology of proteinuria

This SuperSeries is composed of the following subset Series: GSE14666: Expression data from female rat kidney: pathophysiology of proteinuria GSE14676: Expression data from male rat kidney: pathophysiology of proteinuria Refer to individual Series

ORGANISM(S): Rattus norvegicus

2009-02-03 | E-GEOD-14677 | biostudies-arrayexpress

Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology

Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology This model is described in the article: Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology. Yuraszeck TM, Neveu P, Rodriguez-Fernandez M, Robinson A, Kosik ...

2024-09-02 | BIOMD0000000542 | BioModels

27-Hydroxycholesterol links cholesterol and breast cancer pathophysiology.

The cholesterol metabolite and SERM, 27HC, is the signaling molecule that links cholesterol to breast cancer pathophysiology Hypercholesterolemia is a risk factor for breast cancer, and patients taking statins demonstrate lower breast cancer incidence and decreased breast cancer recurrence, data tha...

ORGANISM(S): Homo sapiens

2013-08-01 | E-GEOD-46924 | biostudies-arrayexpress

Redox Imbalance in COVID-19 Pathophysiology

PRJNA873078 | ENA

Sex- and age-associated factors drive the pathophysiology of MASLD

PRJNA1148454 | ENA

Genetics and Pathophysiology of Autoinflammatory Disorders

PRJNA552920 | ENA

Genetics and Pathophysiology of Autoinflammatory Disorders

PRJNA552921 | ENA

The role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome

Schnitzler’s syndrome (SchS) is a disabling autoinflammatory disorder, characterized by chronic urticaria a chronic urticarial rash, an M-protein, arthralgia, and other signs of systemic inflammation. Anti-interleukin-1 (IL-1) beta antibodies are highly effective, but the pathophysiology is still la...

ORGANISM(S): Homo sapiens

2015-08-01 | E-GEOD-70019 | biostudies-arrayexpress