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TranscriptomicsMolecular Evaluation of Patient-Derived Colorectal Cancer Explants as a Pre-clinical Mouse Model of Colorectal Cancer
Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided important information with regard to the mechanisms underlying the oncogenic process, xenograft models re...
ORGANISM(S): Homo sapiens 
2012-06-06 | E-GEOD-35144 | biostudies-arrayexpress
ProteomicsIdentification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants
Proteomic analysis of patient-derived explants from prostate cancer tumors in two independent cohorts--discovery (n=16) and validation (n=30)--in the presence of control or two different hsp90 inhibitors.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-04-05 | MSV000082244 | MassIVE
TranscriptomicsGlobal DNA methylation comparison of olfactory neurosphere-derived cells, fibroblasts and induced pluripotent stem cells derived from the same schizophrenic donors
Epigenetics describes mechanisms via which the environment can act on the genome, including DNA methylation of promoter regions of genes. This could be a way that environmental risk factors could affect neurodevelopment in individuals at risk for schizophrenia. Patient-derived cells provide a means ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-2154 | biostudies-arrayexpress
UnknownPatient-Derived Explants as a Precision Medicine Patient-Proximal Testing Platform Informing Cancer Management.
Not available
S-EPMC8721047 | biostudies-literature
TranscriptomicsCharacterization of an Oxaliplatin Sensitivity Predictor in a preclinical Murine Model of Colorectal Cancer
Despite advances in contemporary chemotherapeutic strategies, long term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this stu...
ORGANISM(S): Homo sapiens 
2012-02-17 | E-GEOD-28691 | biostudies-arrayexpress
UnknownHarnessing the Heterogeneity of Prostate Cancer for Target Discovery Using Patient-Derived Explants.
Not available
S-EPMC8996971 | biostudies-literature
UnknownAntitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants.
Not available
S-EPMC4671492 | biostudies-literature
UnknownUse of patient-derived explants as a preclinical model for precision medicine in colorectal cancer: A scoping review.
Not available
S-EPMC10564805 | biostudies-literature
TranscriptomicsRNA of Small Cell Lung Cancer Circulating Tumour Cells Derived Explants
RNA-seq data characterising small cell lung cancer within circulating tumour cell (CTC) derived explants, generated within immune compromised mice. Both chemo naive and progression models were taken from patients and their drug sensitivity tested within the mouse models. Blood samples were taken fro...
ORGANISM(S): Homo sapiens 
2020-04-26 | E-MTAB-8465 | biostudies-arrayexpress
GenomicsHomo sapiens
Patient derived explants for PRDX3 inhibitor study
PRJNA1292377 | ENA
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