Patient-derived xenografts

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Unknown (2543)
Genomics (1451)
Transcriptomics (712)
Proteomics (149)
Other (41)
Methylation profiling (32)
Metabolomics (15)
Genomic (5)
Clinical (4)

Organisms

Homo sapiens (1219)
Mus musculus (128)
Bombyx mori (88)
Onchocerca volvulus (88)
Klebsiella pneumoniae (88)
Musca domestica (88)
Brugia malayi (88)
Schizosaccharomyces pombe (88)
Cnidaria (88)
Streptomyces coelicolor A3(2) (88)
Sus scrofa (88)
Human immunodeficiency virus 1 (88)
Oryza sativa Indica Group (88)
Sinorhizobium meliloti BL225C (88)
Vitis (88)
Sus scrofa domesticus (88)
Ostreococcus tauri (88)
Saccharomyces cerevisiae (88)
Synechocystis sp. PCC 6803 (88)
Olavius algarvensis Gamma 1 endosymbiont (88)
Vitis vinifera (88)
Saccharopolyspora erythraea (88)
Staphylococcus aureus (88)
Danio rerio (2)
Rattus norvegicus (1)
Homo sapiens/Mus musculus xenograft (1)
Drosophila melanogaster (1)
Gallus gallus (1)
synthetic construct (1)
Fusarium sinicum (1)

Organisms

Homo sapiens (693)
Mus musculus (76)
Homo sapiens/Mus musculus xenograft (2)
Mammalia (1)

Repository

ENA (938)
geo (671)
EGA (396)
biostudies-arrayexpress (232)
pride (88)
MassIVE (36)
MetaboLights (13)
iProX (10)
LINCS (8)
dbGaP (5)
jPOST (5)
GNPS (2)
GPMDB (2)
PanoramaPublic (2)
PAXDB (1)

Tissue

Cell culture (23)
Epithelial cell (11)
Permanent cell line cell (6)
Breast cancer cell (5)
Brain (4)
Primary cell (3)
Leukocyte (3)
Blood (3)
Breast (3)
Kidney (3)
Neuroblastoma cell line (2)
Pancreatic ductal adenocarcinoma cell (2)
Mammary gland epithelial cell (2)
Breast cancer cell line (2)
HEK-293T cell (2)
Melanocyte (2)
Cerebellum (2)
Bone marrow (2)
Blood cell (2)
Cell suspension culture (2)
Lung (2)
Pancreas (2)
Leukemia cell line (1)
B-cell lymphoma/leukemia 11B (1)
Neuroectodermal tumor cell (1)
Liposarcoma cell (1)
Pancreatic ductal adenocarcinoma cell line (1)
Pancreatic stellate cell (1)
Mammary luminal epithelial cell (1)
Pancreatic acinar cell (1)

Disease

Breast cancer (17)
Acute leukemia (6)
Neuroblastoma (5)
Melanoma (4)
Colorectal cancer (3)
Prostate cancer (3)
Brain cancer (3)
Lung cancer (3)
Not Available (2)
Pancreatic ductal carcinoma (2)
Brain glioblastoma multiforme (2)
Hepatocellular carcinoma (2)
Malignant neoplasm of ovary (2)
Pancreatic ductal adenocarcinoma (2)
Colon cancer (2)
Giant Cell Glioblastoma (1)
Normal (1)
Carcinoma, Hepatocellular (1)
Carcinoma (1)
Thyroid gland anaplastic carcinoma (1)
Luminal breast carcinoma (1)
Alveolar rhabdomyosarcoma (1)
Oligodendroglioma (1)
Rhabdomyosarcoma (1)
B-cell acute lymphoblastic leukemia (1)
Myxoid liposarcoma (1)
Pancreatic carcinoma (1)
Embryonal rhabdomyosarcoma (1)
Blastic plasmacytoid dendritic cell neoplasm (1)
Triple-receptor negative breast cancer (1)

Technology Type

Mass Spectrometry (88)
Shotgun proteomics (52)
Bottom-up proteomics (20)
Affinity purification coupled with mass spectrometry proteomics (13)
Mass spectrometry assay (8)
Data-dependent acquisition (8)
Mass spectrometry (5)
Data-independent acquisition (5)
Illumina HiSeq 2000 (4)
Fluorescence intensity (4)
Fluorescence imaging (4)
Mass spectrometry (3)
Illumina HiSeq 2000, ILLUMINA (2)
Gel-based experiment (2)
SWATH MS (2)
Infinium_OmniExpress-24v1.0 (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 4000, Illumina HiSeq 2500 (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, Illumina MiSeq (1)
ILLUMINA, Illumina HiSeq 2000 (1)
RNA-seq (1)
DNA sequencing (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Orbitrap Fusion Lumos (12)
Q Exactive (11)
Illumina HiSeq 2000 (10)
Illumina HiSeq 4000 (9)
Illumina HiSeq 2500 (8)
Illumina NovaSeq 6000 (8)
NextSeq 500 (8)
NextSeq 550 (5)
Q Exactive HF (5)
LTQ Orbitrap Elite (3)
Q Exactive Plus (3)
Instrument (2)
Orbitrap Exploris 480 (2)
Orbitrap Eclipse (2)
Illumina Hybridisation Oven (1)
10x Chromium Controller (1)
MoFlo Legacy cell sorter (Beckman Coulter) (1)
PC (1)
Qiagen MinElute (1)
Illumina iScan (1)
BD FACSARIA II (1)
Affymetrix GeneChip Scanner 3000 (1)
GeneChip Scanner 3000 7G (1)
Illumina Genome Analyzer IIx (1)
Illumina NovaSeq X (1)
QE-HF-x (1)
TimsTOF HT (1)
TimsTOF fleX (1)
TripleTOF 5600 (1)
Orbitrap Exploris 240 (1)

Publication Date

2026 (135)
2025 (123)
2024 (99)
2023 (90)
2022 (90)
2020 (77)
2021 (71)
2018 (59)
2016 (59)
2015 (57)
2019 (51)
2014 (45)
2017 (36)
2013 (22)
2012 (20)
2011 (11)
2010 (8)
2008 (5)
2009 (4)
2005 (1)
2027 (1)

UNIPROT ID/AC

KLF17_HUMAN (1)
CAPSL_HUMAN (1)
FGF22_HUMAN (1)
OR8B2_HUMAN (1)
CAD15_HUMAN (1)
SVOPL_HUMAN (1)
ZN862_HUMAN (1)
ZBT41_HUMAN (1)
FUT2_HUMAN (1)
OR5DE_HUMAN (1)
CKLF1_HUMAN (1)
P12L2_HUMAN (1)
MPIP2_HUMAN (1)
SH24B_HUMAN (1)
MKX_HUMAN (1)
O51B2_HUMAN (1)
TRPM5_HUMAN (1)
FBX48_HUMAN (1)
CCD70_HUMAN (1)
TOB2_HUMAN (1)
CA146_HUMAN (1)
CQ107_HUMAN (1)
IPIL1_HUMAN (1)
K1257_HUMAN (1)
CT096_HUMAN (1)
PIDD1_HUMAN (1)
ONCM_HUMAN (1)
GOG6A_HUMAN (1)
FXL14_HUMAN (1)
CAHM4_HUMAN (1)

CHEBI ID

CHEBI:61040 (1)
CHEBI:191640 (1)
CHEBI:145755 (1)
CHEBI:15245 (1)
CHEBI:191252 (1)
CHEBI:137271 (1)
CHEBI:73215 (1)
CHEBI:176456 (1)
CHEBI:84324 (1)
CHEBI:89188 (1)
CHEBI:37755 (1)
CHEBI:190598 (1)
CHEBI:70961 (1)
CHEBI:193556 (1)
CHEBI:76980 (1)
CHEBI:89312 (1)
CHEBI:183109 (1)
CHEBI:84153 (1)
CHEBI:133649 (1)
CHEBI:133647 (1)
CHEBI:165864 (1)
CHEBI:132479 (1)
CHEBI:142440 (1)
CHEBI:26073 (1)
CHEBI:133677 (1)
CHEBI:133693 (1)
CHEBI:165872 (1)
CHEBI:77042 (1)
CHEBI:166485 (1)
CHEBI:30413 (1)

Metabolite Name

LPE(P-16:0) (2)
LPC(18:0/0:0) (2)
LPC(17:0/0:0) (2)
N1-Methyl-4-pyridone-3-carboxamide (2)
SM(d18:1/18:0) (2)
2'-O-methylcytidine (2)
LPC(18:2/0:0) (2)
[(Aminocarbonyl)(methyl)amino]acetic acid (1)
2-Amino-3-methyl-imidazo[4,5-f]quinoline (IQ) (1)
Unkown (1)
TG(18:2_22:5_22:6) (1)
TG(18:2_20:5_22:6) (1)
TG(18:1_22:5_22:6) (1)
TG(18:1_22:1_22:6) (1)
TG(18:1_20:1_22:6) (1)
TG(18:0_20:4_22:6) (1)
TG(18:0_20:0_22:0) (1)
TG(18:0_16:1_24:6) (1)
TG(17:1_18:1_26:1) (1)
TG(17:0_18:0_18:0) (1)
TG(17:0_17:0_19:1) (1)
TG(16:0_18:0_24:0) (1)
TG(15:0_16:1_22:6) (1)
TG(15:0_15:0_15:1) (1)
TG(14:0_15:0_16:1) (1)
TG(13:0_14:0_16:0) (1)
TG(12:0_15:0_16:1) (1)
SHexCer(d18:1/16:0) (1)
PE(P-20:0_22:5) (1)
PE(P-18:1_21:1) (1)

First Public Date

2026 (141)
2025 (131)
2024 (125)
2023 (100)
2022 (84)
2020 (73)
2021 (63)
2018 (55)
2019 (49)
2017 (42)
2014 (33)
2016 (23)
2015 (18)
2013 (1)

Study status

Not yet recruiting (2)
Recruiting (2)

Study type

Transcription profiling by array (127)
RNA-seq of coding RNA (39)
Methylation profiling by array (13)
Comparative genomic hybridization by array (9)
ChIP-seq (7)
Genotyping by array (6)
Human - High-throughput sequencing (4)
Cell line - High-throughput sequencing (3)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Observational (3)
Unknown experiment type (2)
Human - One-color microarray (2)
ATAC-seq (2)
DNA-seq (2)
Proteomic profiling by array (2)
Methylation profiling by high throughput sequencing (2)
Human - Methylation microarray (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
RNA-seq of total RNA (1)
Interventional (1)

Release Date

2022 (299)
2021 (292)
2020 (267)
2023 (250)
2024 (244)
2025 (242)
2019 (221)
2018 (207)
2017 (190)
2016 (169)
2015 (152)
2014 (90)
2013 (43)
2026 (40)
2012 (26)
2011 (15)
2010 (13)
2009 (5)
2008 (4)
2005 (1)

Lab affiliation

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (2)
Massachusetts Institute of Technology (2)
Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford School of Medicine Stanford University (2)
Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA (1)
Heidelberg University Hospital, Department of Neurology (1)
Gottfried Schatz Research Center for Cell Signaling, Metabolism & Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria (1)
Department of Drug Design and Pharmacology. University of Copenhagen. Denmark (1)
Zhejiang University,China (1)
University of Minnesota, Twin-Cities, Pharmacology Department (1)
University of Minnesota, Twin-cities Pharmacology Department (1)
Beth Israel Deaconess Medical Center, Harvard Medical School, Broad Institute (1)
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Professor of Chemistry Department of Chemistry Duke University (1)
Senior Group Leader (1)
National Institute for Cellular Biotechnology, Dublin City University (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu. Esplugues de Llobregat, 08950 Barcelona, Spain (1)
Peking University Cancer Hospital & Institute. (1)
Medical Research Institute, Wuhan University (1)
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland (1)
Sunnybrook Research Institute, Toronto, ON, Canada / Department of Biochemistry, University of Toronto, Toronto, ON, Canada / Department of Biochemistry and Molecular Biology, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada / Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (1)
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, School of Pharmacy, Jinan University, Guangzhou, 510632, China (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Anonymity for double-blind review (1)
Department of Internal Medicine V, Heidelberg University Hospital, 69120 Heidelberg, Germany (1)
Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva, and Swiss Cancer Center Leman, Geneva, Switzerland (1)
QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane QLD 4006, Australia (1)
SPARC Biocentre, The Hospital for Sick Children, Program in Cell Biology, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto. (1)
Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, New York, United States (1)
German Cancer Research Center, Heidelberg (1)

Location

Japan (2)
Hong Kong (1)
China (1)

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A platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...

ORGANISM(S): Homo sapiens

2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress

Thoracic patient-derived xenografts

PRJNA339191 | ENA

Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

Patient-derived Human Breast Cancer Xenografts

Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-...

ORGANISM(S): Homo sapiens

2013-05-30 | E-GEOD-46106 | biostudies-arrayexpress

scRNA-seq of pediatric glioblastoma patient-derived xenografts

PRJNA482625 | ENA

Illumina Infinium HumanMethylation EPIC Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts

Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.

ORGANISM(S): Homo sapiens

2026-03-31 | E-MTAB-16762 | biostudies-arrayexpress

Illumina Infinium HumanMethylation 450k Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts

Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.

ORGANISM(S): Homo sapiens

2026-03-31 | E-MTAB-16763 | biostudies-arrayexpress

Patient-derived xenografts in multiple myeloma

PRJNA1404307 | ENA

Patient-derived xenografts in multiple myeloma

PRJNA1404306 | ENA

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenografts

Translational breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. In an effort to overcome these limitations, we propagated a cohort of human breast tumo...

ORGANISM(S): Homo sapiens

2013-06-25 | E-GEOD-34412 | biostudies-arrayexpress

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