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MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria (L.saccharolytica;Standards assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS2885 | MetaboLights
ProteomicsS. cerevisiae engineered chassis for dicarboxylic acid production
Chassis strain suitable for producing multiple compounds is a central concept in synthetic biology. Design of a chassis using computational, first-principle, models is particularly attractive due to the predictability and control it offers, including against phenotype reversal due to adaptive mutati...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-20 | PXD020611 | Pride
Yeast Adaptive laboratory evolution Chassis cell 
ProteomicsProteomics for Roseburia intestinalis and Parabacteroides merdae exposed to isosteviol and duloxetine.
The objective of this project was to identify changes in protein expression in R. intestinalis and P. merdae as a response to the treatment with the antidepressant duloxetine, the sweetener isosteviol and a combination of both. 18 samples before and after treatment were collected for each of the two...
ORGANISM(S): Parabacteroides merdae Roseburia intestinalis 
2026-04-30 | PXD045140 | Pride
Proteomics Antidepressant duloxetine Gut bacteria Sweetener isosteviol 
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1792 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1757 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1791 | MetaboLights
ProteomicsThermal proteome profiling in Clostridium saccharolyticum
We used thermal proteome profiling (TPP) to study the thermostability of Clostridium saccharolyticum in the presence of duloxetine.
ORGANISM(S): [Clostridium] saccharolyticum 
2021-07-01 | PXD016064 | Pride
Clostridium saccharolyticum Duloxetine Thermal proteome profiling 
ProteomicsThermal proteome profiling in Escherichia coli
We used thermal proteome profiling (TPP) to study the thermostability of Escherichia coli strains in the presence of duloxetine.
ORGANISM(S): Escherichia coli 
2021-07-01 | PXD016062 | Pride
Escherichia coli Duloxetine Thermal proteome profiling 
ProteomicsTrait tacking for predictive evolution of metabolic pheotypes
Adaptive laboratory evolution is highly effective for improving desired traits through natural selection. However, its applicability is inherently constrained to growth-correlated traits precluding traits of interest that incur a fitness cost, such as metabolite secretion. Here, we introduce the con...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-07-12 | PXD023171 | Pride
Ale s. cerevisiae wine aroma 
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria (E.coli;C.saccharolyticum;S.salivarius;E.rectale;L.plantarum;L.lactis assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1627 | MetaboLights
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