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GenomicsDynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
Linker histones are essential components of chromatin but the distributions and functions of many during cellular differentiation is not well understood. Here, we show that H1.5 binds to genic and intergenic regions, forming blocks of enrichment, in differentiated human cells from all three embryoni...
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-26967 | biostudies-arrayexpress
TranscriptomicsDynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
Linker histones are essential components of chromatin but the distributions and functions of many during cellular differentiation is not well understood. Here, we show that H1.5 binds to genic and intergenic regions, forming blocks of enrichment, in differentiated human cells from all three embryoni...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-41761 | biostudies-arrayexpress
TranscriptomicsGene expression profile of H1.5 knockdown and SIRT1 knockdown IMR90 cells versus control cells
In humans, there are eleven subtypes of linker histones that exhibit cell- and tissue-specific expression. Linker histone H1 proteins bind to both the core histones and linker DNA of chromatin fibers; and not only participate in control of gene activity but also serve to stabilize higher order chrom...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-26856 | biostudies-arrayexpress
TranscriptomicsGene expression profile of H1 human embryonic stem cells, IMR90 lung fibroblasts, calcium induced keratinocytes, and primary hepatocytes
In humans, there are eleven subtypes of linker histones that exhibit cell- and tissue-specific expression. Linker histone H1 proteins bind to both the core histones and linker DNA of chromatin fibers; and not only participate in control of gene activity but also serve to stabilize higher order chrom...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-26855 | biostudies-arrayexpress
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