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TranscriptomicsRate of elongation by RNA polymerase II is influenced by specific gene features and histone modifications
The rate of transcription elongation plays important roles in the timing of expression of full-length transcripts as well as for the regulation of alternative splicing. In this study we coupled Bru-Seq technology with 5,6-dichlorobenzimidazole 1-M-NM-2-D-ribofuranoside (DRB) to estimate the elongati...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-55534 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a M-bM-^@M-^\cleavable complexM-bM-^@M-^]. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment aff...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-48678 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human osteosarcoma
Profiling of DNA copy number changes in human osteosarcomas using array CGH
ORGANISM(S): Homo sapiens 
2009-06-25 | E-MEXP-1219 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human osteosarcoma cell lines
Comparative genomic hybridisation of 20 osteosarcoma cell lines using a homemade 1 Mb BAC/PAC microarray.
ORGANISM(S): Homo sapiens 
2010-02-10 | E-MEXP-1750 | biostudies-arrayexpress
UnknownJust one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii.
Not available
S-EPMC1502489 | biostudies-literature
ProteomicsBRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
Inter-organellar communication is critical for cellular metabolic homeostasis. One of the most abundant inter-organellar interactions are those at the endoplasmic reticulum and mitochondria contact sites (ERMCS). However, a detailed understanding of the mechanisms governing ERMCS regulation and thei...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD056917 | Pride
Endoplasmic reticulum-mitochondria contact sites Bromodomain protein Mitochondrial electron transport chain. High-throughput screening 
TranscriptomicsInactivation of the GacA response regulator in Pseudomonas fluorescens Pf-5 has far-reaching transcriptomic consequences
The GacS/GacA signal transduction system is a central regulator in Pseudomonas spp., including the biological control strain P. fluorescens Pf-5, in which GacS/GacA controls the production of secondary metabolites and exoenzymes that suppress plant pathogens. A whole genome oligonucleotide microarra...
ORGANISM(S): Pseudomonas fluorescens Pf-5 
2010-03-03 | E-GEOD-16898 | biostudies-arrayexpress
UnknownRegulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.
Not available
S-EPMC7505984 | biostudies-literature
UnknownComplete genome sequence of Caulobacter crescentus.
Not available
S-EPMC31192 | biostudies-literature
UnknownAge-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
Not available
S-EPMC8631592 | biostudies-literature
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