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MetabolomicsSETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia
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ORGANISM(S): Homo sapiens 
ST002323 | MetabolomicsWorkbench
TranscriptomicsBrd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release
Distal enhancers characterized by H3K4me1 mark play critical roles in developmental and transcriptional programs. However, potential roles of specific distal regulatory elements in regulating RNA Polymerase II (Pol II) promoter-proximal pause release remain poorly investigated. Here we report that a...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-51633 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing and its regulation by c-Myc in embryonic stem cells: ChIP-chip
Recruitment of the RNA Polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA binding transcription factors is well recognized as a key regulatory step in gene expression. We describe here evidence that promoter-proximal pausing is a general feature of transcription ...
ORGANISM(S): Mus musculus 
2010-04-02 | E-GEOD-20529 | biostudies-arrayexpress
GenomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [ChIP-Seq]
Heart failure is driven by the interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. Coordinate activation of developmental, inflammatory, fibrotic and growth regulators underlies the hallmark phenotypes of pathologic cardiac hypertrophy and contra...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-46668 | biostudies-arrayexpress
GenomicsTranscriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming (ChIP-seq)
Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-59828 | biostudies-arrayexpress
TranscriptomicsTranscriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming (RNA-seq)
Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-59813 | biostudies-arrayexpress
TranscriptomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [RNA-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60585 | biostudies-arrayexpress
GenomicsIntegrator complex regulates NELF-mediated RNA Polymerase II pause/release and processivity at coding genes [ChIP-seq]
RNAPII pausing/termination shortly after initiation is a hallmark of gene regulation. However, the molecular mechanisms involved are still to be uncovered. Here, we show that NELF interacts with Integrator complex subunits (INTScom) forming a stable complex with RNPII and Spt5. The interaction betwe...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-60584 | biostudies-arrayexpress
TranscriptomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [NRVM Expression]
Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylat...
ORGANISM(S): Rattus norvegicus 
2013-08-06 | E-GEOD-48111 | biostudies-arrayexpress
TranscriptomicsBET Bromodomains Mediate Transcriptional Pause Release in Heart Failure [Mouse Heart Expression]
Heart failure (HF) is driven via interplay between master regulatory transcription factors and dynamic alterations in chromatin structure. While pathologic gene transactivation in this context is known to be associated with recruitment of histone acetyl-transferases and local chromatin hyperacetylat...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-48110 | biostudies-arrayexpress
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