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TranscriptomicsThe Functional Consequences of Variation in Transcription Factor Binding
One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene expression outputs, yet the regul...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-50588 | biostudies-arrayexpress
TranscriptomicsGenetic Variation, Not Cell Type of Origin, Underlies Regulatory Differences in iPSCs [Expression]
Analysis of contribution of cell type of origin and individual to gene expression differences in iPSCs. The hypothesis tested in the present study was that cell type of origin affects iPSC gene expression. Results show that individual has a much stronger effect than cell type of origin on difference...
ORGANISM(S): Homo sapiens 
2015-01-16 | E-GEOD-65035 | biostudies-arrayexpress
TranscriptomicsGeneration of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics (methylation array)
Comparative studies in primates are extremely restricted because we only have access to a few types of cell lines from non-human apes and to a limited collection of frozen tissues. In order to gain better insight into regulatory processes that underlie variation in complex phenotypes, we must have a...
ORGANISM(S): Pan troglodytes 
2014-09-11 | E-GEOD-61342 | biostudies-arrayexpress
GenomicsGeneration of a Panel of Induced Pluripotent Stem Cells From Chimpanzees: a Resource for Comparative Functional Genomics [ChIP-Seq]
Comparative genomics studies in primates are extremely restricted due to our limited access to samples from non-human apes. In order to gain better insight into the genetic processes that underlie variation in complex phenotypes in primates, we must have access to faithful model systems for a wide r...
ORGANISM(S): Pan troglodytes 
2015-06-17 | E-GEOD-69919 | biostudies-arrayexpress
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