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MetabolomicsPCOS preterm plasma metabolome

This study investigated mid-trimester plasma metabolomic profiles in pregnant women to identify biomarkers associated with Polycystic Ovary Syndrome (PCOS) and preterm birth. A total of 149 participants were categorized into four groups: 32 with PCOS and preterm delivery, 34 with PCOS and term de...

2025-09-09 | MTBLS12968 | MetaboLights
MetabolomicsPolycystic Ovarian Syndrome(PCOS) metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST000726 | MetabolomicsWorkbench
TranscriptomicsExpression data from human cumulus cells isolated from oocytes at MI and MII stages in polycystic ovary syndrome (PCOS) patients
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that is characterized by increased circulating androgen levels, anovulatory infertility, and frequently, insulin resistance and hyperinsulinemia.The abnormity of oocyte nuclear maturity is the main reason for anovulatory i...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-40400 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of polycystic ovarian syndrome (PCOS)
Genome-wide DNA methylation analysis on PCOS using Illumina HumanMethylation 450K BeadChips in 30 PCOS patients and 30 healthy controls Case-control design
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-80468 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis
Polycystic ovary Syndrome (PCOS) is a heterogeneous endocrine disorder that shows evidence of genetic predidposition among affected individuals. We have utilized the Microarray data from granulosa cells of normal and PCOS women for network construction. Human granulosa cells were isolated from ovar...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-34526 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cumulus cells in vitro isolated from polycystic ovary syndrome lean and obese individuals reveals PCOS in lean and obese individuals is associated with different molecular pathways
Objective: The etiology of PCOS is mostly unknown. Existing data support both genetic and environmental factors in its pathogenesis. Design: Prospective case - control study. Setting: University Hospital. Patients: 25 patients undergoing IVF-ICSI treatment. Intervention: Genome-wide oligonucleoti...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle of PCOS patients after pioglitazone therapy
Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-8157 | biostudies-arrayexpress
ProteomicsSuperior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Polycystic ovary syndrome (PCOS) is a heterogeneous condition, of polyhedric pathogenesis and clinical presentation, defined by oligo-/anovulation, hyperandrogenism and/or polycystic ovaries. Metabolic complications are highly common also in patients suffering PCOS, including obesity, insulin resist...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD044134 | Pride
Pcos Glp1 Glp1/gip Glp1/gip/glucagon Glp1/e 
TranscriptomicsTranscription profiling of human omental adipose tissue in women with polycystic ovary syndrome (PCOS)
CONTEXT: The polycystic ovary syndrome (PCOS) is frequently associated with visceral obesity, suggesting that omental adipose tissue might play an important role in the pathogenesis of the syndrome. OBJECTIVE: The objective was to study the expression profiles of omental fat biopsy samples obtained ...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle of women with PCOS reveals reduced expression of mitochondrial oxidative metabolism genes
Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin re...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6798 | biostudies-arrayexpress
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