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TranscriptomicsComparison of gene expression profiles of Jurkat cells with or without PD-1 ligation
CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1)...
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24026 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors and Jurkat cells with or without PD-1 ligation
This SuperSeries is composed of the following subset Series: GSE24026: Comparison of gene expression profiles of Jurkat cells with or without PD-1 ligation GSE24081: Comparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24082 | biostudies-arrayexpress
ProteomicsPD-L1 intracellular interactions that necessitate the TSS motif within the cytoplasmic domain
Lymphatic endothelial cells (LEC) comprise lymphatic vessels that guide immune cells to lymph nodes (LN) and form the subcapsular sinus and cortical and medullary lymphatic structures of the LN. During an active immune response the lymphatics remodel to accommodate the influx of immune cells from th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-01 | MSV000089579 | MassIVE
TranscriptomicsEffects of PD-0332991 on gene expression of human pancreatic ductal adenocarcinoma (PDAC) cell lines
PD-0332991 is a small molecule inhibitor for Cdk4 and Cdk6. It exerted growth inhibitory effects on PDAC cell lines (AsPC-1 and COLO-357). Microarray analysis was used to characterize the changes in gene expression profiles of AsPC-1 and COLO-357 upon PD-0332991 incubation AsPC-1 and COLO-357 cells ...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-39646 | biostudies-arrayexpress
MetabolomicsSex and subtype differences shape the blood metabolome profiles in Parkinson's disease.

Rationale: Sex and type of Parkinson's disease (PD) significantly influence onset age, clinical manifestations, treatment response, disease progression and life expectancy. However, the selective influence of idiopathic and familial forms of PD in disrupting blood metabolome profiles across gende...

2025-09-03 | MTBLS11187 | MetaboLights
GenomicsStreptomyces sp. PD-S100-1 isolate:PD-S100-1
Streptomyces sp. PD-S100-1 isolate:PD-S100-1 Genome sequencing
PRJNA1212226 | ENA
TranscriptomicsIntegrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines. DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-22208 | biostudies-arrayexpress
ProteomicsThe major lysine residues of PD-L1 ubiquitinated by ARIH1
To figure out the major lysine residues of PD-L1 ubiquitinated by ARIH1, mass spectrometry was utilized to identify the ubiquitination site. K271 was identified as the major residues of ubiquitination
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD063222 | Pride
Pd-l1 Arih1 
TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
GenomicsStreptomyces noursei PD-1
Streptomyces noursei PD-1 Genome sequencing and assembly
PRJNA217850 | ENA
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